Vitronectin receptor antagonist bicyclic compounds,...

Details Vitronectin receptor antagonist bicyclic compounds,... Vitronectin receptor antagonist bicyclic compounds,...

2005-01-25

2005-01-25

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S275000, C514S396000, C514S398000, C514S352000, C540S490000, C544S269000, C544S323000, C546S122000, C546S123000, C546S312000, C548S307400

Reexamination Certificate

active

06846833

ABSTRACT:
Compounds of formula (1):wherein:G represents an optionally substituted phenyl or optionally substituted heterocycle, G1and G2being N or C,T1represents —CH2—CH2—, —CH═CH— or ═CH—CH2—, and T2is a bond, or T1represents —CH2— or ═CH— and T2is —CH2—, ═CH—,R5represents —(CH2)m—COOR6,R6and R6′represent hydrogen, alkyl, optionally substituted aryl or optionally substituted arylalkyl,A represents —CO—, —CH2—, ═CH— or —CH═ and W represents —CH—, ═C— or —C═, or A represents —CO— or —CH2— and W represents N,X represents —CO—X1—, —CO—NR6—X1—, —NR6—CO—X1—, —O—X1—, —SO2—NR6—X1— or —S(O)n—X1—,Y represents —Y1—, —Y2—Y1— or —Y1—Y2—Y1—, Y1being an alkylene, alkenylene or alkynylene, and Y2being an arylene, heteroarylene, cycloalkylene or heterocycloalkylene,Z represents —Z1—, —Z10—NR6—, and —Z10—NR6—CO—, Z1being a heteroaryl, heterocycloalkyl, heteroarylalkyl, heterocycloalkylalkyl, fused arylheteroaryl, fused arylheterocycloalkyl, fused heteroarylheterocycloalkyl, fused heterocycloalkylheteroaryl or fused heteroarylheteroaryl, each of which is optionally substituted, or a group,Z2—NR6or Z2—NR6—CO, Z2being a group Z1, alkyl or heteroalkyl, andZ10represents Z1or an alkyl,its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base,and medicinal products containing the same which are useful as vitronectin receptor antagonists.

REFERENCES:
patent: 6239138 (2001-05-01), Ku
patent: 6403578 (2002-06-01), Bondinell et al.
patent: 2806082 (2001-09-01), None
patent: WO 9600730 (1996-01-01), None
patent: WO 9606087 (1996-02-01), None
patent: WO 9814192 (1998-04-01), None
patent: WO 9830542 (1998-07-01), None
patent: WO 9905107 (1999-02-01), None
patent: WO 9915508 (1999-04-01), None

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