Vitro assay for testing gabapentinoid activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C562S507000

Reexamination Certificate

active

06984496

ABSTRACT:
An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activating the MAP kinase signaling pathway, detecting the MAP kinase signal, and screening the gabapentin analogs and derivatives for inhibitory activity against the MAP kinase signal.

REFERENCES:
patent: 6001581 (1999-12-01), Johnson et al.
patent: 9216547 (1992-01-01), None
Sharif and Sharif, “A high throughput system for the evaluation of protein kinase C inhibitors based on Elk 1 transcriptional activation in human astrocytoma cells”,International Journal of Oncology, vol. 14, 1999, pp. 327-335.
Fiore et al., “Activation of p42 Mitogen-Activated Protein Kinase by Glutamate Receptor Stimulation in Rat Primary Cortical Cultures”,Journal of Neurochemistry, vol. 61, No. 5, 1993, pp. 1626-1633.
Sharif, “Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic/glial brain tumor-derived cell lines (Review)”,International Journal of Oncology, vol. 12, 1998, pp. 273-286.
Lewis, et al., “Signal Transduction Through Map Kinase Cascades”,Advances In Cancer Research, vol. 74, 1998. pp 49-139.
Pin and Duvoisin, “Review†: Neurotransmitter receptors I The Metabotropic Glutamate Receptors: Structure and Functions”,Neuropharmacology, vol. 34, No. 1, 1995, pp. 1-26.
Morris, “Gabapentin”,Epilepsia, vol. 40 (Suppl 5), 1999, pp S63-S70.
Ferrier, “Lamotrigine and Gabapentin: Alternatives in the Treatment of Bipolar Disorder”,Neuropsychobiologyvol. 38, 1998, pp. 192-197.
Bryans, et al., “Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents”,Journal of Medicinal Chemistry, vol. 41, No. 11. 1998, pp. 1838-1845.
Purpura, et al., “Structure-Activity Determinants of Pharmcological Effects of Amino Acids and Related Compounds on Central Synapses”,Neurochemistry, vol. 3, 1959, pp 238-268.
Spokes, “Gaba in Huntington's Chorea, Parkinsonism and Schizophrenia”,Adv Exp Med Biol, vol. 123, 1978. pp. 461-473.
Wu, et al., “Abnormalities of Neurotransmitter Enzymes in Huntington's Chorea”,Neurochemical Research, vol. 4, No. 5, 1979, pp. 575-586.
Tian, et al., “Structural Motifs Encoded by Individual Exons of the Human Neurokinin-1 Receptor Gene Interact Differentially with Selective Agonists and Antagonists”, vol. 67, 1996, pp 1191-1199.
Bryans, et al., “3-Substituted GABA Analogs with Central Nervous System Activity: A Review”,Medical Research Review, vol. 19, 1999, pp 149-177.
Hoekstra, et al., “Chemical Development of CI-1008, an Enantiomerically Pure Anticonvulsant”,Organic Process Research & Development, vol. 1,1997, pp 26-38.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Vitro assay for testing gabapentinoid activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vitro assay for testing gabapentinoid activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitro assay for testing gabapentinoid activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3527517

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.