Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-22
2011-03-22
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S018700, C514S411000, C544S261000, C544S327000, C548S308700, C536S026440, C424S001730, C424S001110, C424S001850, C424S009100
Reexamination Certificate
active
07910594
ABSTRACT:
This invention relates to vitamin-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harboring the pathogenic cells, and to a method of preparation of the conjugates. The conjugate is of the general formulain-line-formulae description="In-line Formulae" end="lead"?B-L-Xin-line-formulae description="In-line Formulae" end="tail"?wherein the group B is a vitamin, or an analog or a derivative thereof, that binds to a surface accessible vitamin receptor that is uniquely expressed, overexpressed, or preferentially expressed by a population of pathogenic cells, wherein the group L comprises a cleavable linker, and wherein the group X comprises a mitomycin compound, or an analog or a derivative thereof. An additional therapeutic agent, such as a chemotherapeutic agent, can be administered in combination with the conjugate.
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Louis T. Weinstock,
Leamon Christopher P.
Vlahov Iontcho Radoslavov
Balasubramanian Venkataraman
Barnes & Thornburg LLP
Endocyte, Inc.
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