Vitamin E intermediates and methods for the preparation of (2R,4

Details Vitamin E intermediates and methods for the preparation of (2R,4 Vitamin E intermediates and methods for the preparation of (2R,4

1983-06-28

1985-10-01

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549408, 549410, 260956, C07D31172

Patent

active

045447586

ABSTRACT:
The invention relates to intermediate compounds having the general formula I ##STR1## in which R.sup.1 is H, an alkyl, arylalkyl or an aliphatic acyl radical, preferably a benzyl or acetyl group and wherein X and Y together span an additional bond between the X and Y carrying C atoms (Ia) or in which Y is OH and X is H (Ib) and in which the dotted line can represent an additional bond particularly [2R,1'Z,3'E,7'E]-6-benzyloxy-2,5,7,8-tetramethyl-2-(4',8',12'-trimethyl-tr ideca-1',3',7'-trien-1'-yl)chroman and 6-benzyloxy-2,5,7,8-tetramethyl-2-(1'-hydroxy-4',8',12'-trimethyl-trideca- 3',7'-diene-1'-yl)chroman, as well as compounds and methods of preparing compounds having the general formula II ##STR2## in which Z is one of the groups ##STR3## wherein R.sup.2 is an alkyl group with 1 to 4 carbon atoms preferably CH.sub.3 or C.sub.2 H.sub.5, particularly (3,7,11-trimethyl-trideca-2,6,10-trien-1-yl)triphenylphosphonium chloride and (3,7,11-trimethyl-trideca-2,6,10-trien-1-yl) phosphoric acid dimethylester as well as methods for the preparation of (2R,4'RS,8'RS)-.alpha.-tocopherol and (all-rac)-.alpha.-tocopherol via the new intermediate product.

REFERENCES:
patent: 4138289 (1979-02-01), Barner et al.
patent: 4168271 (1979-09-01), Cardenas et al.
Hackh's Chemical Dictionary, Ed. Julius Grant, McGraw-Hill Book Co., New York, 1969, pp. 16 and 86.

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