Vitamin E and derivatives thereof prevent potassium ion leakage

Details Vitamin E and derivatives thereof prevent potassium ion leakage Vitamin E and derivatives thereof prevent potassium ion leakage

1994-11-16

2000-06-20

Weber, Jon P.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

4351731, 4351733, 435236, 514458, 549408, A01N 102, C12N 1300, C12N 704, A61K 31355, C07D31176

Patent

active

060776595

ABSTRACT:
An improved process is disclosed for photodynamically inactivating viruses in red blood cell containing compositions by adding vitamin E or a derivative thereof, such as Trolox, to the red blood cell and photosensitizer containing composition prior to irradiation. Addition of vitamin E or derivative thereof is protective of the red blood cells but not the viruses to be inactivated. Cells irradiated in this manner exhibit reduced leakage of potassium ion, and reduced loss of negative charges from the cell membrane compared to cells treated in the absence of vitamin E or derivative. Red blood cells sterilized by this method are better preserved during storage and their life-time in the circulation in vivo is enhanced.

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