Vitamin D3 fluorinated analogs

Details Vitamin D3 fluorinated analogs Vitamin D3 fluorinated analogs

1993-11-24

1995-06-27

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, C07C40100

Patent

active

054280290

ABSTRACT:
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, X is H.sub.2 or .dbd.CH.sub.2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis.

REFERENCES:
patent: 4248791 (1981-02-01), DeLuca
patent: 4358406 (1982-11-01), DeLuca et al.
patent: 4613594 (1986-09-01), Baggiolini et al.
patent: 4804502 (1989-02-01), Baggiolini et al.
patent: 5087619 (1992-05-01), Yamada et al.
patent: 5116573 (1992-02-01), Baggioline et al.
patent: 5145846 (1992-09-01), Baggioline et al.
patent: 5281731 (1994-01-01), Deluca et al.
Pinder, et al., J. Pharm. Sci, vol. 56 (8) (1967), pp. 970-973.
Farach-Carson et al., Endocrinology 129:1876-1884 (1991).
Zhou et al., Blood 78:75-82 (1991).
Shiuey et al., J. Org. Chem. 55:243-247 (1990).
Kiegiel et al., Tetrahedron Letters 32:6057-6060 (1991).

Affiliated with

Also associated with

Rating

Vitamin D3 fluorinated analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vitamin D3 fluorinated analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitamin D3 fluorinated analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-287659