Vitamin D3 analogs useful for reversing the photodamage in sun-e

Details Vitamin D3 analogs useful for reversing the photodamage in sun-e Vitamin D3 analogs useful for reversing the photodamage in sun-e

1997-05-16

1998-09-22

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

058114149

ABSTRACT:
The use of compounds of formula I as topical agents to combat the disorders of the skin, produced by photodamage, which disorders include wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein R is hydrogen, fluorine, or hydroxy, R.sub.2 is hydrogen, lower alkyl or halogen, X is .dbd.CH.sub.2 or when R is hydroxy X is hydrogen or .dbd.CH.sub.2, ##STR2## --CH.sub.2 --CH.sub.2 --, provided that when A is --CH.sub.2 --CH.sub.2 --, R.sub.2 is hydrogen or lower alkyl.

REFERENCES:
patent: 4603146 (1986-07-01), Kligman
patent: 5087619 (1992-02-01), Baggiolini et al.
Chemical Abstracts vol. 102: 119659m (Dikstein et al.) 1985.
The Merck Manual 16th ed. p. 2499 1992.
Kligman, et al., J. Invest. Dermatol. 78:181-189 (1982).
Johnston, et al. J. Invest. Dermatol 82:587-590 (1984).
Kligman, et al., Conn. Tissue Res. 12;139-150 (1984).

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