Vitamin D3 analogs useful for reversing the photodamage in sun-e

Details Vitamin D3 analogs useful for reversing the photodamage in sun-e Vitamin D3 analogs useful for reversing the photodamage in sun-e

1997-09-17

1998-09-08

Chiares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

058045740

ABSTRACT:
The use of compounds of formula I as topical agents to combat the disorders of the skin, produced by photodamage, which disorders include wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein R.sub.1 is hydrogen, hydroxy or fluorine, R.sub.2 is hydrogen or halogen and A is --C.tbd.C--, --C.dbd.C-- or --CH.sub.2 --CH.sub.2 --, provided that when A is --CH.sub.2 --CH.sub.2 --, R.sub.2 is hydrogen.

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patent: 5451574 (1995-09-01), Baggiolini
patent: 5476661 (1995-12-01), Pillai et al.
Kligman et al. J. Invest. Dermatol. 78:181 (1982).
Johnson et al. J. Invest. Dermatol. 82:587 (1984).
Uitto et al. Lab. Invest. 499-505 (1983).
Kligman et al. Conn. Tissue Res. 12:139 (1984).
Int. Congr. Ser. Excerpta Med. vol. 1021, (1993) pp. 479-482.
Skin Pharmacol. vol. 4, No. Suppl 1, (1991) pp. 85-94.

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