Vitamin D3 analogs useful for reversing the photodamage in sun-e

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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A61K 3159

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active

057474796

ABSTRACT:
The use of compounds of formula I as topical agents to combat the disorders of the skin, produced by photodamage, which disorders include wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein R.sub.1 is hydrogen, hydroxy or fluorine, R.sub.2 is hydrogen or halogen and A is --C.vertline.C--, --C.dbd.C-- or --CH.sub.2 --CH.sub.2 --, provided that when A is --CH.sub.2 --CH.sub.2 --, R.sub.2 is hydrogen.

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patent: 5451574 (1995-09-01), Baggiolini
patent: 5476661 (1995-12-01), Pillai et al.
Int. Congr. Ser. Excerpta Med. vol. 1021, 1993 pp. 479-482.
Skin Pharmacol. vol. 4, No. Suppl 1, 1991, pp. 85-94.
Kligman et al. J. Invest. Dermatol. 78:181 (1982).
Johnson et al. J. Invest. Dermatol. 82:587 (1984).
Uitto et al. Lab. Invest. 499-505 (1983).
Kligman et al. Conn. Tissue Res. 12:139 (1984).

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