Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1985-11-20
1987-05-19
Schenkman, Leonard
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07J 900
Patent
active
046666346
ABSTRACT:
A 1.alpha.-hydroxy vitamin D.sub.3 derivative of the formula: ##STR1## where R.sub.1 is a hydroxyl group, an amino group or the group: OR' (where R' is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy group having 1 to 3 carbon atoms, an amino group, or an acylamino group); R.sub.2 is a hydrogen atom or a hydroxyl group), and a process for preparing the same are disclosed.
The compound represented by the formula above has the calcium control action and the ability to induce differentiation in tumor cells and, therefore, are useful as an antitumor agents and a medicine for treating calcium dysbolism-caused diseases.
REFERENCES:
patent: 4011250 (1977-03-01), Ishikawa et al.
Kubodera Noboru
Matsunaga Isao
Miyamoto Katsuhito
Murayama Eigoro
Ochi Kiyoshige
Chugai Seiyaku Kabushiki Kaisha
Lipovsky Joseph A.
Schenkman Leonard
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