Vitamin D.sub.3 analogues

Details Vitamin D.sub.3 analogues Vitamin D.sub.3 analogues

1994-08-02

1995-04-04

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, C07C40100

Patent

active

054038324

ABSTRACT:
A vitamin D.sub.3 analogue which includes a hydroxyalkyl substituent in the 1-position and a modified D-ring side chain is described. This novel compound is a potent anti-proliferative substance with activity comparable to that of calcitriol but with a vitamin D.sub.3 receptor binding rating of approximately 10.sup.-3 compared to that of calcitriol.

REFERENCES:
patent: 4011250 (1977-03-01), Ishikawa et al.
patent: 4666634 (1987-05-01), Miyamoto et al.
patent: 5260290 (1993-11-01), DeLuca et al.

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