Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1998-09-29
1999-08-17
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A61K 3159, C07C40100
Patent
active
059394080
ABSTRACT:
Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R.sub.2 is lower alkyl or C(R.sub.3).sub.3 and R.sub.3 is halogen, X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2, and A is --C.tbd.C-- ##STR2## or --CH.sub.2 --CH.sub.2 --, which are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, and sebaceous gland diseases.
REFERENCES:
patent: 5087619 (1992-02-01), Baggiolini et al.
patent: 5446034 (1995-08-01), Bretting et al.
Cancer Research vol. 55, Jul. 1, 1995, pp. 2822-2830.
Abstract corresponding to JP 07188281, 1995.
Batcho Andrew David
Hennessy Bernard Michael
Iacobelli Jerome Anthony
Uskokovic Milan Radoje
Hoffman-La Roche Inc.
Johnston George W.
Lambkin Deborah C.
Rocha-Tramaloni Patricia S.
Silverman Robert A.
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