Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-05-03
1985-06-04
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 181, 2603972, 514169, A01N 3100, A61K 3170
Patent
active
045214107
ABSTRACT:
A compound which is biologically active in maintaining calcium and phosphorous metabolism in animals, selected from the group consisting of formula (IA) and (IB): ##STR1## wherein the bond between carbons C-22 and C-23 is single or double; Y is hydrogen, F, --CH.sub.3 or --CH.sub.2 CH.sub.3 ; Z is F, H or X; Y' is H, --CH.sub.3 or --CH.sub.2 CH.sub.3 ; Z' is F or H; Q.sup.a is CF.sub.3 or CH.sub.2 X; Q.sup.b is CF.sub.3 or CH.sub.3 ; X is selected from the group consisting of hydrogen and --OR.sup.1, wherein R.sup.1 is hydrogen or an orthoester glycoside radical of the formula (II) ##STR2## where A represents a glucofuranosyl or glucopyranosyl ring; R.sup.2 is hydrogen, lower alkyl, aralkyl, or aryl; and R.sup.3 is hydrogen or a straight or branched chain glycosidic residue containing 1-100 glycosidic units per residue; with the proviso that at least one of the R.sup.1 is an orthoester glycoside moiety of formula (II).
REFERENCES:
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Peterlik, M. et al., FEBS Letters, 56: 16-19, (1973).
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Holick Michael F.
Holick Sally A.
Roberts Elbert L.
The General Hospital Corporation
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