Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1998-07-17
2000-09-26
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A61K 3159, C07C40100
Patent
active
061242764
ABSTRACT:
1.alpha.-hydroxy-vitamin D derivatives represented by formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group; and R.sub.2 represents a straight-chain or branched C.sub.2 -C.sub.7 alkyl, C.sub.2 -C.sub.7 alkenyl, or C.sub.2 -C.sub.7 alkynyl group. The compounds exhibit calcium metabolism regulating activity and differentiation stimulating activity on tumor cells, and are useful as treating agents for diseases caused by abnormal calcium metabolism, such as osteoporosis and osteomalacia, or as antitumor agents.
REFERENCES:
patent: 4011250 (1977-03-01), Ishiwaka et al.
patent: 5389622 (1995-02-01), Posner et al.
patent: 5661140 (1997-08-01), DeLuca et al.
Cho, Cheon-Gyu, Asymmetric intramolecular diels-alder cycloadditions of 2-pyrone carboxylates and application toward an enantiospecific total synthesis of 1.beta.,25-(OH)2,2.beta.-butylvitamin D3. Development of novel inducers of anticarcinogenic detox, 1994.
Posner et al, "Stereocontrolled Total Synthesis of Calcitriol Derivatives: 1,25-Dihydroxy-2-(4'-hydroxbutyl) Vitamin D.sub.3 Analogs for an Osteoporosis Drug", J. Org. Chem. 59:7855-7861 (1994).
Kubodera Noboru
Miyamoto Katsuhito
Badio Barbara
Chugai Seiyaku Kabushiki Kaisha
Dees Jos,e G.
LandOfFree
Vitamin D derivative with substituent at the 2.beta.-position does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vitamin D derivative with substituent at the 2.beta.-position, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitamin D derivative with substituent at the 2.beta.-position will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2100309