Vitamin D compounds with anti-progesterone activity

Details Vitamin D compounds with anti-progesterone activity Vitamin D compounds with anti-progesterone activity

1993-08-20

1995-03-14

Henley, III, Raymond G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

053977769

ABSTRACT:
A birth control method for a female mammal which comprises administering to the mammal an amount of a vitamin D compound sufficient to block binding of progesterone to the progesterone receptor in said mammal.

REFERENCES:
Kumar et al. Vitamin D and Calcium Hormones in Pregnancy. N. Eng. J. Med. 1980; 302(20); 1143-4.
"Synthesis and Biological Activity of 3.beta.-Hydroxy-9,10-Secopregna-5,7,10[19]-Triene-20-One: A Side Chain Analogue of Vitamin D.sub.3 ", Murari et al, Biochem, vol. 17, 1982, pp. 615-619.

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