Vitamin D compounds and method of preparing these compounds

Details Vitamin D compounds and method of preparing these compounds Vitamin D compounds and method of preparing these compounds

1993-06-04

1995-09-12

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514555, A61K 3124, A61K 31205

Patent

active

054496683

ABSTRACT:
The invention relates to a new vitamin D compound of the general formula ##STR1## wherein: R.sub.1 is a hydrogen atom or a hydroxy group;

REFERENCES:
patent: 4866048 (1989-09-01), Calverley et al.
patent: 5190935 (1993-03-01), Binderup et al.
patent: 5206229 (1993-04-01), Calverley et al.
Journal of Organic Chemistry, vol. 58, No. 1, 1 Jan. 1993, Easton, U.S., pp. 118-123, J. P. Sestelo et al., "Ultrasonically induced conjugate addition of iodides to electron-deficient olefins and its application to the synthesis of side-chain analogs of the hormone 1-alpha-25-dihydroxyvitamin D3".
Bioorganic & Medicinal Chemistry Letters, vol. 3, No. 2, 1993, Oxford, GB, pp. 341-344, S. R. Wilson et al., "Chemistry of the new immunosuppressant KH-1060: New synthons and X-ray evidence for unique side-chain geometry".
Chemical and Pharmaceutical Bulletin, vol. 38, No. 5, May 1990, Tokyo, JP, pp. 1246-1249, T. Eguchi et al., "Effect on carbon lengthening at the side chain terminal of 1-alpha-25-dihydroxyvitamin D3 for calcium regulating activity".
Farach-Carson et al, Endocrinology 129 (4), 1991, pp. 1876-1884 [Abstract only available.]
Sestelo et al, J. Org. Chem., 1993, 58, pp. 118-123, "Ultrasonically Induced Conjugate Addition of Iodides to . . . ".

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