Vitamin D analogues

Details Vitamin D analogues Vitamin D analogues

1986-02-10

1988-09-20

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

047724331

ABSTRACT:
Compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a hydroxyl protecting group, Y represents a hydrogen atom or an optionally protected hydroxyl group, X represents the residue of a dienophile and either R.sup.1 represents a halogen atom a hydrocarbylsulphonyloxy group or a group of the formula --Z--R.sup.3 (in which Z represents --O--, --S--, --SO--, --NR.sup.4 -- or --CR.sup.4 R.sup.5 -- and R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom or a straight or branched aliphatic group having 1-12 carbon atoms and which may optionally carry one or more substituents) and R.sup.2 represents a hydrogen atom or R.sup.1 and R.sup.2 together represent an oxo group or an optionally substituted alkylidene group, except that R.sup.1 and R.sup.2 together with the group --CH(CH.sub.3)CH-- to which they are attached do not represent a group having the branched 17.beta.-hydrocarbyl side chain skeleton of vitamin D.sub.2 or vitamin D.sub.3 or use in the preparation of novel vitamin D analogues.

REFERENCES:
patent: 3741996 (1973-06-01), DeLuca et al.
The Merck Index, 9th Ed., 1976, pp. 9677-9680.
J. Org. Chem. (1976), vol. 41, Article by Aberhart et al., pp. 2098-2101.
"Chemistry Letters" (1976), pp. 583-586, Article by Yamalda et al.

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