Vitamin D analogues

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

552653, C07C40100

Patent

active

054017327

ABSTRACT:
##STR1## The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in which one or more hydroxy groups have been transformed into --O-acyl or --O-glycosyl or phosphate ester groups, such masked groups being hydrolyzable in vivo, in pure form or in mixtures. The present compounds find use in both the human and veterinary practice in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus, hypertension, inflammatory diseases such as rheumatoid arthritis and asthma as well as diseases characterized by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.

REFERENCES:
Abe, et. al. "Synthetic analogues of vitamin D.sub.3 with an oxygen atom in the side chain skeleton" FEB 05407, vol. 226, No. 1, pp. 58-62 (Dec. 1987).
Chemical Pharm. Bull., vol. 34, No. 10, 1986 Eigoro Murayama et al.: "Synthetic Studies of Vitamin D3 Analogues. VIII Synthesis of 22-oxavitamin D3 Analogues." see pp. 4410-4413.
Chemical Abstracts, vol. 108, No. 11, Mar. 1988, Junko et al, "Synthetic Analogs of Vitamin D3 with an oxygen atom in the side chain skeleton." see abstract 8819v, & FEBS Lett. 1987, 226 (1) 58-62.
Chemical Abstracts, vol. 110, No. 2, Jan. 1989, Katsuhito et al.: "Antitumor pharmaceuticals containing 9, 10-seco-5, 7, 10 (19)-pregnatriene derivatives." see abstracts 13599s & Jpn Kokai Tokkyo Koho JP 63107930, May 1988.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Vitamin D analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vitamin D analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitamin D analogues will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2250644

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.