Vitamin D amide derivatives

Details Vitamin D amide derivatives Vitamin D amide derivatives

1995-12-07

1997-11-11

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514169, 5142275, 5142375, 514261, 514319, 514372, 514374, 514399, 514406, 514415, 514423, 514886, 544 59, 544176, 544264, 546195, 546205, 548200, 548214, 5483341, 5483415, 5483741, 5483611, 548491, 548530, 548540, 548579, 552501, 552544, 552547, 552505, 552653, 564188, 564189, A61K 3159, C07C40100

Patent

active

056864353

ABSTRACT:
The invention pertains to vitamin D amide derivatives of formula (I). These novel 1.alpha.-hydroxy vitamin D derivatives and their 20-epi analogues comprise compounds of formula (I) and corresponding 5,6-trans isomers, where Y represents an alkylene or alkenylene group containing up to four carbon atoms; R.sup.1 and R.sup.2 independently represent a hydrogen atom or a lower alkyl or cycloalkyl group, or R.sup.1 R.sup.2 N-- represents a heterocyclic group; and R.sup.3 and R.sup.4 independently represent a hydrogen atom or an O-protecting group. Active compounds, in which R.sup.3 and R.sup.4 are hydrogen atoms or metabolically labile O-protecting groups exhibit potent cell modulating effect, but minimal effect on calcium metabolism.

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Yamada et al. J. Med. Chem., 1985, 28, 1148-1150.
Kabakoff et al.; Archives Of Biochemistry And Biophysics, vol. 221, No. 1, 1983, pp. 38-45.
Calverley, Tetrahedron Letters, vol. 43, No. 20, pp. 4609-4619, 1987.

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