Vitamin-containing granules and production thereof

Details Vitamin-containing granules and production thereof Vitamin-containing granules and production thereof

1986-10-01

1989-09-19

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514345, 514355, 514563, 514781, A61K 31525, A61K 3144, A61K 31195, A61K 4700

Patent

active

048681806

ABSTRACT:
A vitamin-containing granule comprising one or more compounds selected from the group consisting of vitamin B.sub.6, vitamin B.sub.2, nicotinamide and a pantothenic acid salt, and a binding agent, said compound or compounds accounting for 90 to 99 weight percent of the granules on the dry basis, can be prepared by spray-coating the powders of said compound or compounds with a solution containing a binder while maintaining the powders in a fluidized state in a fluidized-bed granulation apparatus.
The granules are highly flowable and blend well with other medicaments, granules, additives, and so on. In addition to this, the granules are excellent in compressibility so that they can be processed into tablets with small amounts of excipients, and the tablets therefrom have satisfactory high hardness.

REFERENCES:
patent: 3308217 (1967-03-01), Lowy
patent: 3493659 (1970-02-01), Magid
patent: 3907983 (1975-09-01), Seth
patent: 4036948 (1977-07-01), Kitamori et al.
patent: 4372968 (1983-02-01), Kitamori et al.
patent: 4486435 (1984-12-01), Schmidt et al.
patent: 4619829 (1986-10-01), Motschan
patent: 4702918 (1987-10-01), Ushimaru et al.
patent: 4702919 (1987-10-01), Kitamori et al.

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