Vitamin B12 conjugates with EPO, analogues thereof and pharmaceu

Details Vitamin B12 conjugates with EPO, analogues thereof and pharmaceu Vitamin B12 conjugates with EPO, analogues thereof and pharmaceu

1993-05-24

1996-08-20

Robinson, Douglas W.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530399, 536 264, 536 2641, C07H 2300, C07K 200

Patent

active

055480640

ABSTRACT:
The invention describes complexes between VB.sub.12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB.sub.12 portion of the complex and significant bioactivity of the GCSF or EPO portion of the complex. The invention also concerns a process for the synthesis of these complexes. This is achieved at least in part, by using a spacer compound, which is linked covalantly between the VB.sub.12 portion and the GCSF or EPO. The complexes preferably have the formula

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