Vitamin B.sub.12 mediated oral delivery systems for GCSF

Details Vitamin B.sub.12 mediated oral delivery systems for GCSF Vitamin B.sub.12 mediated oral delivery systems for GCSF

1996-05-22

1999-02-09

Knode, M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

530350, 536 264, 536 2644, A61K 3170, C07H 2300, C07K 100

Patent

active

058694668

ABSTRACT:
The invention describes complexes between VB.sub.12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB.sub.12 portion of the complex and significant bioactivity of the GCSF or EPO portion of the complex. The invention also concerns a process for the synthesis of these complexes. This is achieved at least in part, by using a spacer compound, which is linked covalantly between the VB.sub.12 portion and the GCSF or EPO. The complexes preferably have the formula

REFERENCES:
patent: 3876765 (1975-04-01), Choay
patent: 3962416 (1976-06-01), Katzen
patent: 4007266 (1977-02-01), Choay
patent: 4235869 (1980-11-01), Schwartzberg
patent: 4672040 (1987-06-01), Josephson
patent: 4677195 (1987-06-01), Hewick et al.
patent: 4732889 (1988-03-01), Cynshi et al.
patent: 4745099 (1988-05-01), Akamatsu et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 5026826 (1991-06-01), Evans et al.
patent: 5071834 (1991-12-01), Burton et al.
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5206219 (1993-04-01), Desai
patent: 5292802 (1994-03-01), Rhee et al.
patent: 5308889 (1994-05-01), Rhee et al.
patent: 5548064 (1996-08-01), Russell-Jones et al.
deKlerk et al., "Serum Erythropoietin (ESF) Titers in Anemia." Blood, 58(6), 1164-1170 (Dec. 1981).
Neiman et al., "Carcinogenic Agents and Reactions of Organism in Response to Them," Patol. Fiziol. Eksp. Ter., 1972(4), 14-18; Chem. Abstr., 77(25), p. 73, Abstr. No. 160683t (Dec. 18, 1972); only Abstract supplied.
Babior (ed.), Cobalamin--Biochemistry and Pathophysiology, Wiley-Intescience, New York, 1975, p. 25.
Chan et al., "Pharmacokinetics and Metabolism of LHRH Analogs," Ch. 37 in LHRH and Its Analogs; Contraception and Therapeutic Applications Part 2, Vickery & Nestor eds., Kluwer Academic Publishers, Norwell, MA, 1987, pp. 577-593.
Kwan et al., "Biopharmaceutics," Ch. 9 in The Theory and Practice of Industrial Pharmacy, Lochman, Lieberman & Kanig eds., Williams and Wilkins, 1986, pp. 197-242.

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