Vitamin B.sub.12 derivative, preparation process thereof, and us

Details Vitamin B.sub.12 derivative, preparation process thereof, and us Vitamin B.sub.12 derivative, preparation process thereof, and us

1993-08-11

1995-04-11

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 264, 536 2641, A61K 3168, C07H 2300

Patent

active

054058392

ABSTRACT:
Vitamin B.sub.12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from the group consisting of a cyano or adenosyl group, B is an imidazole group or a 5,6-dimethylbenzimidazole group, and R is a straight alkylene group having 1 to 8 carbon atoms, are disclosed. Methods for preparing compounds of Formula (I) as well as methods for using the compounds in in vitro assays, in cell growth studies and in in vivo studies using transplanted murine tumor cells are disclosed.

REFERENCES:
"Inorganic Chemistry of Vitamin B.sub.12 ", by J. M. Pratt, Academic Press, 1972 pp. 156-159.
G. L. Matevosyan et al., "Preparation of Phosphorylated Benzimidazoles", Journal of General Chemistry of the USSR, vol. 52, No. 7, part 1, Jul. 1982 pp. 1275-1286.

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