Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1995-04-21
1996-09-17
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 45, 514725, A61L 904, A61K 914, A01N 3104
Patent
active
055566111
ABSTRACT:
A pharmaceutical preparation consisting of retinoic acid and/or an ester of retinoic acid and/or an ester of retinol as active substances, which are present in the preparation form of aerosol, is advantageously suitable for topical treatment of mucosal diseases in man and animal.
REFERENCES:
patent: 5112598 (1992-05-01), Biesalski
H. K. Biesalski, et al. Biochemical, Morphological, and Functional Aspects of Systemic and Local Vitamin A Deficiency in the Respiratory Tract. Sep. 30, 1992. vol. 669. Ann NY Acad. Sci. pp. 325-331.
Biesalski, H. K., "Effects of intra-tracheal application of vitamin A on concentrations of retinol derivatives in plasma, lungs and selected tissues of rats," Int. J. Vit. Nutr. Res. (in press).
Biesalski, H. K., et al., "Bioavailability of inhalative application of vitamin A. Comparison with intramuscular and oral administration," Bioavailability 93, Schlemmer, U. (ed.), BfE 336-345 (1993).
McDowell, E. M., et al, "Effects of viatamin A deprivation on hamster tracheal epithelium," Virchows Arch. (Cell Pathol.) 45:197-219 (1984).
Edmondson, S. W., et al. "Regulation of differentiation and keratin protein expression by vitamin A in primary cultures of hamster epithelial cells," J. Cell Physiol. 142:21-30 (1990).
Stofft, E., et al., "Morphological changes in the tracheal epithelium of guinea pigs in conditions of `marginal` vitamin A deficiency," Int. J. Vit. Nutr. Res. 62:134-142 (1992).
Lasnitzki, I., et al., "Prevention and reversal by a retinoid of 3,4-benzpyrene- and igarette smoke condensate-induced hyperplasia and metaplasia of rodent respiratory epithelia in organ culture," Canc. Treat Rep. 66:1375-1380.
McDowell, E. M., et al., "Restoration of mucociliary tracheal epithelium following deprivation of vitamin A.," Virchows Arch. (Cell Pathol.) 45:221-240 (1984).
Sommer, A., et al., "Increased mortality in children with mild vitamin A deficiency," Lancet 585-588 (Sep. 10, 1983).
Sommer, A., et al., "Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency," Am J. Clin. Nutr. 40:1090-1095 (1984).
Sommer, A., et al., "Vitamin A supplementation and childhood mortality," Nutrition Reviews 45(2):48-50 (1987).
Fawzi, W. W., et al., "Vitamin A supplementation and childhood mortality: A metaanalysis," JAMA 269:898-903 (1993).
Milton, R. C., et al., "Mild vitamin A deficiency and childhood mobidity--an Indian expreience," Am J. Clin. Nutr. 46:827-829 (1987).
Pinnock, C. B., et al., "Vitamin A status of children when a history of respiratory syncytial virus infection in infancy," Aust. Paediatr. J. 24:286-289 (1988).
Pinnock, C. B., et al., "Vitamin A status in children who are prone to respiratory tract infections," Aust. Paediatr. J. 22:95-99 (1986).
Mathe, G., et al., "Detection of precancerous bronchus metaplasia in heavy smokers and its regression following retinoid treatment," Modulation and mediation of cancer by vitamins, 317-321 (1983).
Gouveia, J., et al., "Degree of bronchial metaplasia in heavy smokers and its regression after treatment with a retinoid," Lancet 27:710-712 (1982).
Biesalski, H. K., et al., "Supplementary vitamin A improves pulmonary function," Lancet (submitted) (1995).
Hustead, V. A., "Relationship of vitamin A (retinol) status to lung disease in the preterm infant," J. Pediatr. 105(4):610-615 (1984).
Zachman, R. D., "Retinol (vitamin A) and the neonate: special problems of the human premature infant," Am. J. Clin. Nutr. 50:413-424 (1989).
Zachman, R. D., et al., "Retinyl ester synthesis by isolated adult rabbit lung type II cells," Int. J. Vit. Nutr. Res. 58:161-165 (1988).
Zachman, R. D., et al., "Perinatal rat lung retinol (vitamin A) and retinyl palmitate," Pediatr. Res. 18(12):1297-1299 (1984).
Rutten, A., et al., "Effects of all-trans retinol and cigarette smoke condensate on hamster tracheal epithelium in organ culture. I. A cell proliferation study," Virch. Arch. B Cell Pathol. 55:167-175 (1988).
Rutten, A., et al., "Effects of all-trans retinol and cigarette smoke condensate on hamster tracheal epithelium in organ culture. II. A histomorphological study," Virch. Arch. B Cell Pathol. 55:177-186 (1988).
Morabia, A., et al., "Vitamin A, cigarette smoking and airway obstruction," Am. Rev. Resp. Dis. 140:1312-1316 (1989).
Morabia, A., et al., "Serum retinol and airway obstruction," Am. J. Epidemiol. 132(1):77-82 (1990).
Gerlach, et al., "Vitamin A in parenteral nutrition: uptake and distribution of retinyl esters after intravenous application," Am. J. Clin. Nutr. 50:1029-1038 (1989).
Edes, T. E., et al., "Exposure to the Carcinogen Benzopyrene Depletes Tissue Vitamin A. .beta.-Carotene Prevents Depletion," Nutr. Cancer 15:159-166 (1991).
Azpuru Carlos
Hermes Fabrik pharmazeutischer Praparate
LandOfFree
Vitamin A aerosol-inhalant preparations and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vitamin A aerosol-inhalant preparations and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitamin A aerosol-inhalant preparations and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-411526