Visualization polymers and their application to diagnostic medic

Details Visualization polymers and their application to diagnostic medic Visualization polymers and their application to diagnostic medic

1983-06-10

1987-08-18

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 7, 435 14, 435 21, 435 25, 435 28, 435188, 435810, 436501, 436504, 436537, 436545, 436546, 436800, 436801, 436804, 436808, 436827, G01N 3353, G01N 33533, G01N 33534, G01N 33535

Patent

active

046877320

ABSTRACT:
A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or indirect means, a visualization polymer. The visualization polymer is composed of multiple units of a visualization monomer which are covalently linked together directly or indirectly covalently linked together by coupling agents which bond to chemical groups of the monomer. The monomer may be an enzyme, a tagged polypeptide, a tagged polyol, a tagged polyolefin or a tagged carbohydrate. The detecting agent may be an antibody, an enzyme, a lectin, strand of a DNA receptor protein, avidin, streptavidin and the like. The visualization polymer produces a high degree of amplification for the detection of the target molecule.

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Langer, P. R. et al., Proc. Natl. Acad. Sci. USA, 78 (11), 6633-6637, (Nov. 1981).

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