Visualization of a bloodstream circulation with biodegradable mi

Details Visualization of a bloodstream circulation with biodegradable mi Visualization of a bloodstream circulation with biodegradable mi

1985-03-15

1987-07-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

A61K 4904

Patent

active

046801715

ABSTRACT:
An inexpensive and easy to use method of visualizing an arterial circulation using biodegradable microspheres dyed with an X-ray absorbent material, which enables the diagnosis of pulmonary embolism, is provided. The microspheres may be comprised of a variety of materials, including human albumin, and may be dyed with a number of X-ray absorbent materials, including hypaque-sodium and potassium iodide. The microspheres are injected into bloodstream at a particular location such that they travel through the desired arterial circulation, where they become lodged. Upon exposure of the arterial circulation to X-rays, blood vessels therein containing the microspheres will absorb the X-rays, causing them to show on a developed X-ray in contrast to other blood vessels and body tissue which do not contain the microspheres that transmit the X-rays. The microspheres are designed to dissolve into the bloodstream within fifteen to thirty minutes after their introduction, the X-ray dye being ultimately excreted from the body via the urine or metabolized by the liver.

REFERENCES:
patent: 3984571 (1976-10-01), Chen
patent: 4192859 (1980-03-01), MacKaness et al.
patent: 4285928 (1981-08-01), Wada et al.

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