Visual function disorder improving agents

Details Visual function disorder improving agents Visual function disorder improving agents

2006-09-19

2006-09-19

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S352000, C514S343000, C514S332000, C514S329000, C514S326000

Reexamination Certificate

active

07109208

ABSTRACT:
The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.

REFERENCES:
patent: 4456757 (1984-06-01), Hidaka et al.
patent: 4678783 (1987-07-01), Hidaka et al.
patent: 5478838 (1995-12-01), Arita et al.
patent: 5733904 (1998-03-01), Fujii et al.
patent: 5747507 (1998-05-01), Ikegaki et al.
patent: 5906819 (1999-05-01), Kaibuchi et al.
patent: 5958944 (1999-09-01), Arita et al.
patent: 6153608 (2000-11-01), Hidaka et al.
patent: 6156766 (2000-12-01), Arita et al.
patent: 6218410 (2001-04-01), Uehata et al.
patent: 6329547 (2001-12-01), Shirasawa et al.
patent: 6673812 (2004-01-01), Azuma et al.
patent: 2002/0032148 (2002-03-01), Uehata et al.
patent: 2003/0158413 (2003-08-01), Takanashi et al.
patent: 728480 (1986-08-01), None
patent: 0 609 822 (1994-08-01), None
patent: 609822 (1994-08-01), None
patent: 0 728 480 (1996-08-01), None
patent: 1 034 793 (2000-09-01), None
patent: 1034793 (2000-09-01), None
patent: 1 064 944 (2001-01-01), None
patent: 1064944 (2001-01-01), None
patent: 1 256 574 (2002-11-01), None
patent: 62-89679 (1987-04-01), None
patent: 2-256617 (1990-10-01), None
patent: 3/218356 (1991-09-01), None
patent: 4-264030 (1992-09-01), None
patent: 4-273821 (1992-09-01), None
patent: 6-041080 (1994-02-01), None
patent: 6-293643 (1994-10-01), None
patent: 7-041424 (1995-02-01), None
patent: 7-277979 (1995-10-01), None
patent: 9-227381 (1997-09-01), None
patent: 10-087491 (1998-04-01), None
patent: 10-113187 (1998-05-01), None
patent: 10-201 480 (1998-08-01), None
patent: 10 201 480 (1998-08-01), None
patent: 10-201480 (1998-08-01), None
patent: 2001-08 1048 (2001-03-01), None
patent: 2001-81048 (2001-03-01), None
patent: 94/05290 (1994-03-01), None
patent: 97/19694 (1997-06-01), None
patent: 97/23222 (1997-07-01), None
patent: 98/06433 (1998-02-01), None
patent: 98/34485 (1998-08-01), None
patent: 99/00133 (1999-01-01), None
patent: 99/23113 (1999-05-01), None
patent: 00/57914 (2000-10-01), None
Hirose, Masaya et al., “Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remolding in Neuroblastoma N1E-115 Cells”, The Journal of Cell Biology, vol. 141, No. 7, Jun. 29, 1998, pp. 1625-1636.
Lehmann, Maxine et al., “Inactivation of Rho Signaling Pathway CNS Axon Regeneration”, Journal of Neuroscience, vol. 19, No. 17, Sep. 1, 1999, pp. 7537-7547.
Bito, Haruhiko et al., “A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons”, Neuron, vol. 26, May 2000, pp. 431-441.
Bulletin of the Japanese Society for Neurochimistry, vol. 40, Nos. 2 and 3, 2001, p. 253 (S47-6).
Naunyn-Schmiedeberg's Archives of Pharmacology, Supplement to vol. 358, No. 1, 1998, p. R219.
Hirose, M. et al., “Molecular Dissection of the Rho-associated Protein Kinase (160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells.”, J. Cell. Biol., 1998, 141 (7), pp. 1625-1636.
Lehamann, M., et al., “Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration”. J. Neurosci., 1999, 19 (17), pp. 7537-7547.
Bito, H., et al., “A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammaliman CNS neurons.” Neuron, 2000, 26(2), pp. 431-441.
McKerracher, L. “Strategies to promote regeneration of adult rat renal ganglion cell axons in the nerve.” Bullet of the Japanese Society for Neurochemistry, 2001 4 (2/3), pp. 253 (S47-6).

Affiliated with

Also associated with

Rating

Visual function disorder improving agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Visual function disorder improving agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Visual function disorder improving agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3542583