Vision through photodynamic therapy of the eye

Details Vision through photodynamic therapy of the eye Vision through photodynamic therapy of the eye

1998-05-22

1999-06-08

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514912, A61K 31295

Patent

active

059105100

ABSTRACT:
Photodynamic therapy of conditions of the eye, especially those conditions characterized by unwanted neovasculature, such as age-related macular degeneration, results in enhanced visual acuity for treated subjects.

REFERENCES:
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Schmidt-Erfurth, U. et al., Investigative Ophthalmologny& Visual Science, vol. 37, No. 3, p. 580 (1996): "Photodynamic Therapy of Subfoveal Choroidal Neovascularization Using Benzoporphyrin Derivative: First Results of a Multi-Center Trial".
Bunse, A. et al., Investigative Ophthalmology& Visual Science, vol. 37, No. 3, p. S223 (1996): "Photodynamic Therapy of Chorodal Neovascularization: Effects on Retinal Function Documented by Microperimetry".
Miller, J.W. et al., Archives of Ophthalmology, vol. 113, No. 6, pp. 810-818 (1995): "Photodynamic Therapy of Experimental Choroidal Neovasculariation Using Lipoprotein-Delivered Benzoporphyrin".
Young, L.H.Y. et al., Archives of Ophthalmology, vol. 114, No. 2, pp. 186-192 (1996): "Photodynamic Therapy of Pigmented Choroidal Melanomas Using a Liposomal Preparation of Benzoporphyrin Derivative".
Miller et al., Chemical Abstracts, 124:24930, 1995.
Schmidt-Erfurth, U. et al., "Photothrombosis of Ocular Neovasculariation Using Benzoporphyrin Derivative (BPD)," Abstract No. 2956, IOVS (1993) 34:1303.
Haimovici, R. et al., "Localization of Benzoporphyrin Derivative Monoacid in the Rabbit Eye,"Abstract No. 2955, IOVS (1993) 34:1303.
Walsh, A.W. et al., "Photodynamic Therapy of Experimental Choroidal Neovascularization Using Benzoporphyrin Derivative Monoacid," Abstract No. 2954, IOVS (1993) 34:1303.
Lin, S.C. et al, "Photodynamic Closure of Choroidal Vessels Using Benzoporphyrin Derivative," Abstract No. 2953, IOVS (1993)34:1303.
Moultan, R.S. et al., "Response of Retinal and Choroidal Vessels to Photodynamic Therapy Using Benzoporphyrin Derivative Monoacid," Abstract No. 2294, IOVS (1993) 34:1169.
Schmidt,U. et al., "Photosensitizing Potency of Benzoporphyrin Derivative (BPD) Associated with Human Low Density Lipoprotein (LDL)," Abstract No. 2802, IOVS (1992) 33:1253.

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