Viscous compositions containing carbon dioxide

Details Viscous compositions containing carbon dioxide Viscous compositions containing carbon dioxide

2000-08-17

2004-02-10

Krass, Frederick (Department: 1614)

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Gas produced in situ by chemical reaction

C424S401000, C424S464000, C424S466000, C424S043000, C424S700000, C424S078030, C514S817000, C514S828000, C514S858000, C514S887000, C514S944000, C514S945000, C514S947000, C514S960000

Reexamination Certificate

active

06689339

ABSTRACT:

TECHNICAL FIELD
Thee present invention relates to a carbon dioxide-containing viscous composition which is capable of treating or ameliorating itching accompanying mucocutaneous diseases or mucocutaneous disorders such as athlete's foot, insect bite, atopic dermatitis, nummular eczema, xeroderma, seborrheic eczema, urticaria, prurigo, housewives' eczema, acne vulgaris, impetigo, folliculitis, carbuncle, furunculosis, phlegmon, pyoderma, psoriasis, ichthyosis, palmoplantar keratoderma, lichen, pityriasis, wound, burn, rhagades, erosion and chilblain; mucocutaneous injuries such as decubitus ulcer, wound, burn, angular stomatitis, stomatitis, skin ulcer, rhagades, erosion, chilblain and gangrene; incomplete takes of skin graft, skin flap, etc.; dental diseases such as gingivitis, alveolar pyorrhea, denture ulcer, nigricans gingiva, stomatitis; skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders such as thromboangitis obliterans, arteriolosclerosis obliterans, diabetic peripheral circulatory disorder and varicosis in lower extremity; musculoskeletal diseases such as chronic rheumatoid arthritis, cervico-omo-brachial syndrome, myalgia, arthralgia and lumbago; nervous system diseases such as neuralgia, polyarthritis and subcute myelo-optic neuropathy; keratoses such as psoriasis, corn, callosity, ichthyosis, palmoplantar keratoderma, lichen and pityriasis; suppurative dermopathies such as acne vulgaris, impetigo, folliculitis, carbuncle, furunculosis, phlegmon, pyoderma and suppurative eczema; constipation caused by loss of reflection of defecation; suppression of hair re-growth after depilation (treatment of unwanted hair); cosmetic troubles in the skin or hair such as freckles, rough skin, muddy complexion, faded skin complexion and loss of hair glossiness, etc. with little side effects as well as of slimming a desired part of the body, and to prophylactic and therapeutic methods using the composition.
BACKGROUND ART
Antihistamines and antiallergics for external application are typically used in a topical therapy for itching. Such drugs are used when itching occurs and work to suppress the itching temporarily to a certain degree. Itching associated with eczema is generally treated with non-steroidal anti-inflammatory drugs or steroidal drugs for external application which prevent the itching by suppressing inflammation.
However, the antihistamines and antiallergics for external application are barely effective in treating itching accompanying atopic dermatitis, athlete's foot and insect bite. The non-steroidal anti-inflammatory drugs and steroidal drugs for external application do not effect satisfactorily nor immediately on itching. Further, the steroidal drugs are difficult to use because of the serious side effects.
The present invention provides a preparation effective for the treatment of itching accompanying mucocutaneous diseases or mucocutaneous disorders such as athlete's foot, insect bite, atopic dermatitis, nummular eczema, xeroderma, seborrheic eczema, urticaria, prurigo, housewives' eczema, acne vulgaris, impetigo, folliculitis, carbuncle, furunculosis, phlegmon, pyoderma, psoriasis, ichthyosis, palmoplantar keratoderma, lichen, pityriasis, wound, burn, rhagades, erosion and chilblain and therapeutic and prophylactic methods using the preparation.
Further, the invention provides a preparation effective for the treatment of mucocutaneous injuries such as decubitus ulcer, wound, burn, angular stomatitis, stomatitis, skin ulcer, rhagades, erosion, chilblain and gangrene; incomplete takes of skin graft, skin flap, etc.; dental diseases such as gingivitis, alveolar pyorrhea, denture ulcer, nigricans gingiva, stomatitis; skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders such as thromboangitis obliterans, arteriolosclerosis obliterans, diabetic peripheral circulatory disorder and varicosis in lower extremity; musculoskeletal diseases such as chronic rheumatoid arthritis, cervico-omo-brachial syndrome, myalgia, arthralgia and lumbago: nervous system diseases such as neuralgia, polyarthritis and subcute myelo-optic neuropathy; keratoses such as psoriasis, corn, callosity, ichthyosis, palmoplantar keratoderma, lichen and pityriasis; suppurative dermopathies such as acne vulgaris, impetigo, folliculitis, carbuncle, furunculosis, phlegmon, pyoderma and suppurative eczema; constipation caused by loss of reflection of defecation; suppression of hair re-growth after depilation (treatment of unwanted hair); cosmetic troubles in the skin or hair such as freckles, rough skin, muddy complexion, faded skin complexion, loss of hair glossiness, etc. and partial obesity, and prophylactic and therapeutic methods using the preparation.
DISCLOSURE OF INVENTION
The inventors accomplished the present invention as a result of an extensive research wherein they found that a carbon dioxide-containing viscous composition is effective in treating itching which had not been cured by antihistamines, anti-allergics, non-steroidal anti-inflammatory drugs, steroidal drugs for external application or the like and that the composition has an anti-inflammatory action, wound healing accelerating action, skin treatment action, action for resolving partial obesity, transdermal or transmucosal drug absorption promoting action and the like.
The invention relates to the following items 1-48.
1. A carbon dioxide-containing viscous composition comprising an aqueous viscous composition containing one or more thickeners and carbon dioxide, wherein the aqueous viscous composition comprises the carbon dioxide in the form of bubbles.
2. The carbon dioxide-containing viscous composition according to item 1, which is characterized in that the thickener comprises one or more selected from the group consisting of natural polymers, semi-synthetic polymers, synthetic polymers and inorganic substances.
3. The carbon dioxide-containing viscous composition according to item 1 or 2, which is characterized in that the natural polymer used as a thickener is at least one selected from the group consisting of gum arabic, carrageenan, galactan, agar, quince seed gum, guar gum, tragacanth gum, pectin, mannan, locust bean gum, wheat starch, rice starch, corn starch, potato starch, curdlan, xanthan gum, succinoglucan, dextran, hyaluronic acid, pullulan, albumin, casein, collagen, gelatin and fibroin; the semi-synthetic polymer used as a thickener is at least one selected from the group consisting of ethyl cellulose, carboxymethyl cellulose and salts thereof, carboxymethylethyl cellulose and salts thereof, carboxymethyl starch and salts thereof, croscarmellose and salts thereof, crystalline cellulose, cellulose acetate, cellulose acetate phthalate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxypropylmethyl cellulose phthalate, powdered cellulose, methyl cellulose, methylhydroxypropyl cellulose, pregelatinized starch, partially pregelatinized starch, carboxymethyl starch, dextrin, methyl starch, sodium alginate, propyleneglycol alginate, sodium chondroitin sulfate and sodium hyaluronate; the synthetic polymer used as a thickener is at least one selected from the group consisting of carboxyvinyl polymer, sodium polyacrylate, polyvinylacetaldiethylaminoacetate, polyvinyl alcohol, polyvinyl pyrrolidone, methacrylic acid-ethyl acrylate copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate.trimethylammoniumethyl chloride methacrylate copolymer, dimethylaminoethyl methacrylate.methyl methacrylate copolymer; the inorganic substance used as a thickener is at least one selected from the group consisting of silicon dioxide hydrate, light anhydrous silicic acid, colloidal alumina, bentonite and laponite.
4. The carbon dioxide-containing viscous composition according to any one of items 1-3, which is characterized in that the carbon dioxide is produced by reacting an acid or acids with a carbonate or carbonates.
5. The carbon dioxide-containing viscous composition according to item 4, which is characterize

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