Viscoelastic material for ophthalmic surgery

Details Viscoelastic material for ophthalmic surgery Viscoelastic material for ophthalmic surgery

1986-09-04

1989-04-11

Apley, Richard J.

Surgery

Miscellaneous

514912, 536 98, 623 6, A61B 1900

Patent

active

048196177

ABSTRACT:
The present invention embodies a composition particularly adapted for use as an ophthalmic viscosurgical material for use in the anterior chamber of the eye consisting essentially of an aqueous solution preferably having a near physiological pH and osmolarity and containing at least about 1.5%, by weight, of a water soluble physiologically acceptable derivative of carboxymethylcellulose having a molecular weight greater than 500,000 and a degree of substitution (DS) greater than about 0.4, the aqueous solution having a viscosity greater than about 10,000 centipoises.
The invention further embodies an improved ophthalmic viscosurgical procedure wherein the anterior chamber of the eye is filled with a space-filling corneal endothelium and ocular tissue protective surgical material, the improvement comprising the utilization of an ophthalmic surgical material having the above described composition.

REFERENCES:
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patent: 4421748 (1983-12-01), Trager et al.
patent: 4510145 (1985-04-01), Schacher
Fechner, "Methylcellulose in Lens Implantation", J. of Amer. Intraocular Society, vol. 3, (1977), pp. 180-181.
Klug, Encyclopedia of Polymer and Science Tech., vol. 3, (1965), pp. 520-539.
Remington's Pharmaceutical Sciences, 15th Ed., Editor: Arthur Osol, Mack Pub., (1975), pp. 1243-1244.
Wilhelmus et al., "Pseudovitreous Fluid Based on Sodium Carboxymethylcellulose", Annals of Ophthalmology, Apr. 1984, pp. 350-352.

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