Viscoelastic fluid for use in surgery and other therapies and me

Details Viscoelastic fluid for use in surgery and other therapies and me Viscoelastic fluid for use in surgery and other therapies and me

1988-11-03

1991-01-08

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514781, 514912, 514915, A61K 31715, A61K 4700

Patent

active

049835858

ABSTRACT:
This invention relates to an improved viscoelastic fluid or gel for use in surgery and other therapies which consists of polyethylene oxide in selected concentrations not to exceed approximately 15% (15,000 ppm), contained in a physiologic balanced salt solution. The PEO may also be used in conjunction with viscosity enhancers which also act as heat stabilizers such as methyl cellulose and its derivatives, polyvinyl pyrrolidone or polyvinyl, alcohol or in conjunction with elasticizers such as low molecular weight polyethylene glycols or polypropylene glycols or in conjunction with gelation modifiers. These mixtures may be modified to increase retention time in the body by crosslinking with the use of materials like dimethylol urea. The invention encompasses the novel method of protecting and lubricating the corneal tissues during surgery with uses of different concentrations of the same solution introduced simultaneously to protect the inner cornea while periodically irrigating the outer cornea, all without obscuring the surgeon's view of the site. This invention also prevents the development of wound adhesion and has many utilizations in orthopedics.

REFERENCES:
patent: 3856919 (1974-12-01), Rankin
patent: 3947573 (1976-03-01), Rankin

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