Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-17
1998-09-22
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514469, A61K 31355, A61K 3134
Patent
active
058114530
ABSTRACT:
Compounds and methods for treating ocular tissues are disclosed. The methods utilize viscoelastic compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory and proliferative disorders through several mechanisms.
REFERENCES:
patent: 4374258 (1983-02-01), Horner et al.
patent: 4988728 (1991-01-01), Gerson et al.
patent: 5084575 (1992-01-01), Kreft, III et al.
patent: 5166331 (1992-11-01), della Valle et al.
patent: 5424321 (1995-06-01), Hellberg et al.
Eros, et al., Rheology and stability of Cremophor-containing creams. II. Study of cream stability., Chemical Abstracts, vol. 122, No. 22, Abstract No. 272753f (29 May 1995).
Rainsford, K. D., editor, "Volume 1: Inflammation Mechanisms and Actions of Tradtional Drugs", Anti-Inflammatory and Anti-Rheumatic Drugs, CRC Press, Inc., Boca Raton, Florida, pp. 54-68, 79-87, 120-126 and 140-144 (1985).
Bazan, H., "Response of Inflammatory Lipid Mediators following Corneal Injury", Lipid Mediators In Eye Inflammation New Trends Lipid Mediators Res. Basel Karger, vol. 5, pp. 1-11 (1990).
Bellavite, P., "The Superoxide-Forming Enzymatic System Of Phagocytes", Free Radical Biology & Medicine, vol. 4, pp. 225-261 (1988).
Bonne, C. et al., 2-(2-Hydroxy-4-methylphenyl)aminothiazole Hydrochloride as a Dual Inhibitor of Cyclooxygenase/Lipoxygenase and a Free Radical Scavenger, Drug Research, vol. 39(II), No. 10, pp. 1242-1250 (1989).
Campbell, W., "Lipid-Derived Autacoids: Eicosanoids And Platelet-Activiating Factor", Goodman and Gilman's The Pharmacologial Basis Of Therapeutics, Pergman Press, NY, pp. 600-617 (1990).
Chow, C., "Vitamin E And Oxidative Stress", Free Radical Biology & Medicine, vol. II, pp. 215-232 (1991).
Cohen, N. et al., "Lewis Acid Mediated Nucleophilic Substitution Reactions of 2-Alkoxy-3,4-dihydro-2H-Ibenzopyrans: Regiochemistry and Utility in the Synthesis of 3,4-Dihydro-2H-1-benzopyran-2-carboxylic Acids", Journal of Organic Chemistry, vol. 54, pp. 3282-3292 (1989).
Duchstein, H. et al., "Activiated Species of Oxygen: A Challenge to Modern Pharmaceutical Chemistry", Archives of Pharmacology, vol. 325, pp. 129-146 (1992).
Duniec, Z. et al.; "Antioxidant properties of some chemicals vs their influence on cyclooxygenase and lipoxidase activities", Biochemical Pharmacology, vol. 32, No. 14, pp. 2283-2286 (1983).
Gifford, H., "On The Treatment Of Sympathetic Ophthalmia By Large Doses Of Salicylate Of Sodium, Aspirin, Or Other Salicylic Compounds", Ophthalmoscope, vol. 8, pp. 257-259 (1910).
Goa, K. et al., "Ocular Diclofenac", Drugs & Aging, vol. 2(6), pp. 473-486 (1992).
Graff, G. et al., oxyphenyl!Ethanone(AHR-5333): A Selective Human Blood Neutrophil 5-Lipoxygenase Inhibitor", Prostaglandins, vol. 38, No. 4, pp. 473-496 (1989). Human Disease: An Overview", Methods in Enzymology, vol. 186, pp. 1-85 (1990).
Hammond et al., "Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of a potent topical antiinflammatory agent", Journal of Medicinal Chemistry, vol. 33, No. 3, pp. 908-918 (1990).
Hammond et al., "2,3-Dihydro-5-benzofuranols as Antioxidant-Based Inhibitors of Leukotriene Biosynthesis", J. Med. Chem., vol. 32, pp. 1006-1020 (1989).
Hutchinson et al., "Drug Discovery and Development through the Genetic Engineering of Antibiotic-Producing Microorganisms", Journal of Medicinal Chemistry, vol. 32, No. 5, pp. 907-918 (1989).
Insel, P., "Analgesic-Antipyretics And Antiinflammatory Agents: Drugs Employed In The Treatment Of Rheumatoid Arthritis And Gout", Goodman and Gilman's The Pharmacological Basis of Therapeutics, Pergman Press, NY, pp. 638-669 and 681 (1990).
Lamba, O. et al., "Spectroscopic detection of lipid peroxidation products and structural changes in a sphingomyelin model system", Biochimica et Biophysica Acta, vol. 1081, pp. 181-187 (1991).
Momsen, W. et al., "Lipid Structural Reorganization Induced by the Pancreatic Lipase Cofactor, Procolipase", Biochemistry, vol. 34, pp. 7271-7281 (1995).
Nelson, P., "Cyclooxygenase Inhibitors", CRC Handbook of Eicosanoids: Prostqaglandins and Related Lipids, vol. II, Drugs Acting Via the Eicosanoids, CRC Press, Boca Raton, FL, pp. 59-133 (1989).
Pearce et al., "Inhibitors of Cholesterol Biosynthesis. 2. Hypocholesterolemic and Antioxidant Activities of Benzopyran and Tetrahydronaphthalene Analogues of the Tocotrienols", Journal of Medicinal Chemistry, vol. 37, No. 4, pp. 526-541 (1994).
Petty, M., et al.; "Protective effects of an .alpha.-tocopherol analogue against myocardial reperfusion injury in rats", European Journal of Pharmacology, vol. 210, pp. 85-90 (1992).
Sies, H., et al., "Role of tocopherols in the protection of biological systems against oxidative damage", Journal of Photochemistry and Photobiology, vol. 8, pp. 211-224 (1991).
Skoog, W. et al., "Studies on the Fibrinogn, Dextran and Phytochemagglutinin Methods of Isolating Leukocytes", Blood, vol. II, pp. 436-454 (1956).
Smaby, J. M. et al., "Characterization of Lipid Miscibility in Liquid-Expanded Monolayers at the Gas-Liquid Interface", Langmuir, vol. 8, No. 2, pp. 563-570 (1992).
Tseng, C. et al., "Inhibition of in Vitro Prostaglandin and Leukotriene Biosynthesis by Chinnamoyl-.beta.-phenethylamine and N-Acyidopamine Derivatives", Chem. Pharm. Bull., vol. 40, No. 2, pp. 396-400 (1992).
Vane, J. et al., "Inflammation and the mechanism of action of anti-inflammatory drugs", FASEB Journal, vol. 1, pp. 89-96 (1987).
Graff Gustav
Yanni John M.
Alcon Laboratories Inc.
Jordan Kimberly
Mayo Michael C.
LandOfFree
Viscoelastic compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Viscoelastic compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Viscoelastic compositions and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1622150