Viruses with recombinant surface proteins

Details Viruses with recombinant surface proteins Viruses with recombinant surface proteins

1982-01-11

1986-06-03

Hazel, Blondel

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 68, 435 70, 435 71, 435 91, 435235, 435239, 435317, 935 12, 935 31, 935 32, 935 65, 424 89, 424 93, C12N 1500, C12N 700, C12N 702, C12N 100, C12P 2100, C12P 2102, C12P 2104, C12P 1934, A61K 3912, A61K 3700

Patent

active

045930023

ABSTRACT:
Foreign protein segments having specific medically or commercially useful biological functions are incorporated in surface proteins of viruses. The viruses with the incorporated protein segments are convenient agents for introducing the protein segments into animals, such as humans, and are thus useful as vaccines. Small segments of an original protein exhibiting desired functions are identified, and a DNA fragment having a nucleotide base sequence encoding that segment of the protein is isolated from an organism or synthesized chemically. The isolated DNA fragment is inserted into the DNA genome of a virus in a manner such that the inserted DNA fragment expresses itself as the foreign segment of a surface viral protein and in such a way that neither the function of the protein segment nor the function of any viral protein critical for viral replication is impaired.

REFERENCES:
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patent: 4442205 (1984-04-01), Hamer et al.
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Charnay et al., Nature, vol. 286, pp. 893-895, Aug. 1980.
Moriarity et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 4, pp. 2606-2610, Apr. 1981.
Walter et al., Proc. Natl. Acad. Sci. USA, vol. 77, No. 9, pp. 5197-5200, Sep. 1980.

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