Viruses and expression vectors containing LTR size variants

Details Viruses and expression vectors containing LTR size variants Viruses and expression vectors containing LTR size variants

1994-08-18

1998-09-29

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4353201, 435353, 435357, 536 241, 536 245, C12P 1934, C12N 1579, C12N 510, C07H 2104

Patent

active

058144935

ABSTRACT:
The invention relates to virally-encoded nucleic acid sequences derived from a region 5' to the transcriptional start site of the virus which contain at least one direct repeat of a fragment of a hormone-responsive element. In a preferred embodiment, the virus is murine mammary tumor virus, and the hormone-responsive element is a glucocorticoid responsive element.

REFERENCES:
Hsu et al., "Mouse Mammary Tumor Virus Proviruses in T-Cell Lymphomas Lack a Negative Regulatory Element in the Long Terminal Repeat", J. of Virol., vol. 62, No. 12, Dec. 1988, pp. 4644-4652.
Mink et al., "The long terminal repant region of the mouse mannary tumour virus contains multiple regulatory elements", Nucleic Acids Res., vol. 18, No. 8, 1990, pp. 2017-2024.
Schmid et al., "Glucocorticoid receptor binds cooperatively, to adjacent recognition sites," EMBO J., vol. 8, No. 8, 1989, pp. 2257-2263.
Lucas et al., "Hormone Response Domains in Gene Transcription", Annu. Rev. Biochem, 1992, vol. 61, pp. 1131-1173.

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