Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-02-09
1992-07-07
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Lymphokine
A61K 39245
Patent
active
051281287
ABSTRACT:
Provided are a virus vaccine, comprising a properly incapacitated virus lacking an antigen of the wild-type virus which is useful for serologically distinguished between vaccinated and infected animals, methods for distinguishing between vaccinated and infected animals and multivalent vaccines.
REFERENCES:
patent: 4514497 (1985-04-01), Kit et al.
patent: 4609548 (1986-09-01), Kit et al.
patent: 4680176 (1987-07-01), Berns et al.
patent: 4711850 (1987-12-01), Kit et al.
patent: 4810634 (1989-03-01), Post et al.
D. P. Gustafson, "Pseudorabies" in Diseases of Swine, 5th ed., A. D. Leman et al., eds., pp. 209-223 (1981).
T. C. Jones and R. D. Hunt, "Pseudorabies" in Veterinary Pathology, 5th ed., Lea & Febiger, pp. 322-326 (1983).
C. E. Aronson, ed., Veterinary Pharmaceuticals and Biologicals, pp. 15/98-99 (1983).
T. Ben-Porat and A. S. Kaplan, "Synthesis of Proteins in Cells Infected with Herpesvirus" in Virology, 41, pp. 265-273 (1970).
A. S. Kaplan and T. Ben-Porat, "Synthesis of Proteins in Cells Infected with Herpesvirus, VI. Characterization of the Proteins of the Viral Membrane" in Proc. Natl. Acad. Sci. USA, 66, pp. 799-806 (1970).
B. Norrild and B. F. Vestergaard, "Immunoelectrophoretic Identification and Purification of Herpes Simplex Virus Antigens . . . " Intervirology, 11, pp. 104-110 (1979).
R. E. Randall, et al., "Glycoproteins with Type Common and Type Specific Antigenic Sites Excreted from Cells Infected with Herpes Simplex" in J. Gen. Virol., 48, pp. 297-310 (1980).
D. Van Zaane, et al., "Molecular-Biological Characterization of Marek's Disease Virus" in Virology, 121, pp. 116-132 (1982).
R. E. Randall and R. W. Honess, "Proteins of Herpesvirus Saimiri: Identification of Two Virus Polypeptides Released into the Culture Medium of Productively Infected Cells" in J. Gen. Virol., 51, pp. 445-449 (1980).
T. Ben-Porat and A. S. Kaplan, "Synthesis of Proteins in Cells Infected with Herpesvirus" in Virology, 41, pp. 265-273 (1970).
T. J. Rea, et al., "Mapping and Sequence of the Gene for the Pseudorabies Virus Glycoprotein which Accumulates in the Medium of Infected Cells" in J. Virol., 54, pp. 21-29 (1985).
A. L. J. Gielkens, et al., "Genome Differences Among Field Isolates and Vaccine Strains of Pseudorabies Virus," J. Gen. Virol., 66, pp. 69-82 (1985).
B. Lomniczi, et al., "Deletions in the Genomes of Pseudorabies Virus Vaccine Strains and Existence of Four Isomers of the Genomes," J. Virol., 49, pp. 970-979 (1984).
T. C. Mettenleiter, et al., "Mapping of the Structural Gene of Pseudorabies Virus Glycoprotein A and Identification of Two Non-Glycosylated Precursor Polypeptides," J. Virol., 53, pp. 52-57 (1985).
G. Tatarov, "Apathogenic Mutant of the Aujeszky Virus Induced by 5-Iodo-2-Deoxyuridine (IUDR)." Zentralblatt Veterinarmedizin, 15, pp. 847-853 (1968) (translation).
V. Khristova, et al., "Thymidine Kinase Activity of Virulent and Vaccinal Strains of Aujeszky's Disease Virus," Veterinary Science, 22, pp. 15-22 (1982) (translation).
Pablo Valenzuela, et al., "Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles," Biotechnology, 3, pp. 323-326 (1985).
M. P. Kieny, et al., "Expression of rabies virus glycoprotein from a recombinant vaccinia virus," Nature, 312, pp. 163-166 (1984).
T. C. Mettenleiter, et al., "Pseudorabies Virus Avirulent Strains Fail to Express a Major Glycoprotein," Journal of Virology, 56, pp. 307-311 (1985).
M. W. Wathen and L. K. Wathen, J. Virol, 51, pp. 57-62 (1984).
T. C. Holland, et al., J. Virol., 45, pp. 672-682 (1983).
L. W. Post and B. Roizman, Cell, 25, pp. 227-232 (1981).
D. Todd and J. B. McFerran, "Control of Aujeszky's Disease," Vet. Record, 117, p. 647 (1985).
D. R. Thomsen, et al., "Replication and Virulence of Pseudorabies Virus Mutants Lacking Glycoprotein gX," J. Virol, 61, pp. 229-232 (1987).
R. M. Sandri-Goldin, et al., J. Virol., 38, pp. 41-49 (1981).
W. Quint, et al., J. Gen. Virol., 68, pp. 523-534 (1987).
Post Leonard E.
Thomsen Darrell R.
DeLuca Mark
Koivuniemi Paul J.
Nolan S. L.
Schwartz Richard A.
The Upjohn Company
LandOfFree
Virus vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Virus vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Virus vaccine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1828385