Virus-resistant transgenic mice

Details Virus-resistant transgenic mice Virus-resistant transgenic mice

1987-09-03

1992-12-29

Weimar, Elizabeth C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 4353201, 4353171, 935111, C12N 1500

Patent

active

051753855

ABSTRACT:
A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. The gene encodes the interferon of a different animal species and therefore its expression product is less toxic to the host at an embryonic, fetal, neonatal or junvenile stage of development. Preferably, the human beta interferon gene is introduced into the cells of a mouse.

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