Virus inactivation

Details Virus inactivation Virus inactivation

1985-09-17

1989-08-15

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514885, 514934, A61K 31685

Patent

active

048575143

ABSTRACT:
A virus having a lipid-containing capsid, such as AIDS virus, is inactivated by contacting the virus with an inactivating amount of phosphatidyl choline. Such a virus can be inactivated in fluids such as virus-contaminated body fluids or derivatives, e.g., blood or blood derivatives. The phosphatidyl choline can be present in an Active Lipid (AL) composition further comprising neutral lipids and phosphatidyl ethanolamine. Phosphatidyl choline, and an AL composition containing same, is useful for the treatment or prophylaxis of Acquired Immune Deficiency Syndrome (AIDS) in mammals.

REFERENCES:
patent: 4474773 (1984-10-01), Shinitzky et al.
Sarin et al., The New Eng. J. of Med., 313:1289-1290, 1985.
Moore et al., J. Virol., 27:320-329, 1978.
Omar Sattaur, This Week, New Scientist, (Feb. 7, 1985).
M. Popovic et al., Science, 224:497-500, (May 4, 1984).
H. Mitsuya et al., Science, 226:172-174, (Oct. 12, 1984).
R. Soave et al., Anals of Internal Medicine, 199:504-511, (Apr. 1984).
P. Sarin et al., Journal of Clinical Immunology, vol. 4, No. 6, pp. 415-423, (1984).
H. J. Alter et al., Science, 226:549-552.
Pal et al., Biochemistry 20: 530-539, (1981).
Moore et al., Biochemistry 16: 4708-4715, (1977).

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