Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2009-12-03
2011-12-06
Graser, Jennifer (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S185100, C424S190100, C435S975000
Reexamination Certificate
active
08071111
ABSTRACT:
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of aStreptococcus, the method comprising modifying a genomic fragment ofStreptococcuswherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization inStreptococcus suisto a nucleic acid or fragment thereof as shown in FIG.5.
REFERENCES:
patent: 5610011 (1997-03-01), Smith et al.
patent: 5681570 (1997-10-01), Yang et al.
patent: 5733765 (1998-03-01), Mollet et al.
patent: 5786184 (1998-07-01), Mollet et al.
patent: 5928900 (1999-07-01), Masure et al.
patent: 5948900 (1999-09-01), Yother et al.
patent: 5981229 (1999-11-01), Masure et al.
patent: 6699703 (2004-03-01), Doucette-Stamm et al.
patent: 7109006 (2006-09-01), Smith
patent: 7125548 (2006-10-01), Smith
patent: 2002/0055168 (2002-05-01), Smith
patent: 2007/0053938 (2007-03-01), Smith
patent: 0 750 043 (2001-05-01), None
patent: WO 92/16630 (1992-10-01), None
patent: WO 95/06732 (1995-03-01), None
patent: WO 95/31548 (1995-11-01), None
patent: WO 96/21465 (1996-07-01), None
patent: WO 98/19689 (1998-05-01), None
patent: 00/06738 (2000-02-01), None
patent: WO 00/05378 (2000-02-01), None
patent: WO 02/38597 (2002-05-01), None
patent: WO 02/061070 (2002-08-01), None
Murphy et al. Pediatr. Infect. Dis. J. 1989. 8: S66-S68.
Yamanaka et al (J. Pediatrics. 1993. 122(2): 212-218).
Fraser et al (Science. 1998. 281: 375-388).
Nelson et al (Nature. 1999. 399: 323-329).
1997/1998 Stratagene catalog (p. 118, 1997/1998).
Allgaier et al., Relatedness ofStreptococcus suisisolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits. Journal of Clinical Microbiology, 2001, pp. 445-453, vol. 39, No. 2.
Busque et al., Immunization of pigs againstStreptococcus suisserotype 2 infection using a live avirulent strain, Can J Vet Res., Oct. 1997, pp. 275-279, vol. 61, No. 4.
Charland et al.,Streptococcus suisserotype 2 mutants deficient in capsular expression, Microbiology, Feb. 1998, pp. 325-332, vol. 144, No. 2.
Chothia et al., The Embo Journal, 1986, pp. 823-826, vol. 5, No. 4.
Christie et al., Expression of fibronectin-binding protein FbpA modulates adhesion inStreptococcus gordonii, Microbiology, 2002, pp. 1615-1625, vol. 148.
Courtney et al., Cloning, Sequencing, and Expression of a Fibronectin/Fibrinogen-Binding Protein from Group AStreptococci, Infection and Immunity, Sep. 1994, pp. 3937-3946, vol. 62, No. 9.
Database EMBL ‘Online’ McNab,S. gordoniipartial aldB gene, cshA gene & fbpA gene, Database accession No. X65164, XP002213089, 2002.
De Greeff et al., Contribution of Fibronectin-Binding Protein to Pathogenesis ofStreptococcus suisSerotype 2, Infection and Immunity, Mar. 2002, pp. 1319-1325, vol. 70, No. 3.
De Greeff et al., Distribution of Environmentally Regulated Genes ofStreptococcus suisSerotype 2 amongS. suisSerotypes and Other Organisms, Journal of Clinical Microbiology, Sep. 2002, pp. 3261-3268, vol. 40, No. 9.
Dutch Text Annual Report ID-DLOStreptococcus Suis, 1996, with English translation of said report.
Elliott et al., Streptococcal infection in young pigs. V. An immunogenic polysaccharide fromStreptoccoccus suistype 2 with particular reference to vaccination against streptococcal meningitis in pigs, Oct. 1980, pp. 275-285, vol. 85, No. 2.
Kawabata et al., Molecular cloning, sequence and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene, Oral Microbiology and Immunology, 2000, pp. 58-62, vol. 15.
Joh et al., Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells, Matrix Biology, 1999, pp. 211-223, vol. 18.
Kolkman et al., Diversity of capsular polysaccharide synthesis gene clusters inStreptococcus pneumoniae, J. Biochem., May 1998, pp. 937-945, vol. 123, No. 5.
Koskiniemi et al., Identification of two genes, cpsX and cpxY, with putative regulatory function on capsule expression in group B streptococci, FEMS Immunology and Medical Microbiology, 1998, pp. 159-168, vol. 21.
McNab, Cloning and sequence analysis of thymidine kinase from the oral bacteriumStreptococcus gordonii, FEMS Microbiology Letters, 1996, pp. 103-110, vol. 135.
Munoz et al., Characterization of IS1515, a Functional Insertion Sequence inStreptococcus pneumoniae, Journal of Bacteriology, Mar. 1998, pp. 1381-1388, vol. 180, No. 6.
PCT International Preliminary Examination Report, PCT/NL01/00805, dated Sep. 8, 2002, 2 pages.
PCT International Search Report, PCT/NL01/00805, dated Jun. 6, 2002, 3 pages.
Quessy et al., Immunization of mice againstStreptococcus suisserotype 2 infections using a live avirulent strain, Can J. Vet Res., Oct. 1994, pp. 299-301, vol. 58, No. 4.
Roberts et al., The biochemistry and genetics of capsular polysaccharide production in bacteria, Ann. Rev. Microbiol., 1996, pp. 285-315, vol. 50.
Segers et al., Characterisation of the gene encoding suilysin fromStreptococcus suisand expression in field strains, FEMS Microbiology Letters, 1998, pp. 255-261, vol. 167.
Smith et al., Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) ofStreptococcus suistype 2, Infection and Immunity, 1992, pp. 2361-2367, vol. 60, No. 6.
Smith et al., Environmentally regulated genes ofStreptococcus suis: identification by the use of iron-restricted conditions in vitro and by experimental infections of piglets, Microbiology, 2001. pp. 271-280, vol. 147.
Smith et al., High efficiency transformation and gene inactivation inStreptococcus suistype 2, Microbiology, Jan. 1995, pp. 181-188, vol. 141.
Smith et al., Identification and characterization of the cps locus ofStreptococcus suisserotype 2: the capsule protects against phagocytosis and is an important virulence factor, Infect Immun., Apr. 1999, pp. 1750-1756, vol. 67, No. 4.
Smith et al., Mutants ofStreptococcus suisTypes 1 and 2 Impaired in Expression of Muramidase-Released Protein and Extracellular Protein Induce Disease in Newborn Germfree Pigs, Infection and Immunity, Oct. 1996, pp. 4409-4412, vol. 64, No. 10.
Smith et al., Repeats in an extracellular protein of weakly pathogenic strains ofStreptococcus suistype 2 are absent in pathogenic strains, Infection and Immunity, 1993, pp. 3318-3326, vol. 61, No. 8.
Smith et al., Selection of virulence-associated determinants ofStreptococcus suisserotype 2 by in vivo complementation, Infection and Immunity, Mar. 2001, pp. 1961-1966, vol. 69, No. 3.
Smith et al., The cps locus ofStreptococcus suisserotype 2: genetic determinant for the synthesis of sialic acid, Microbial Pathogenesis, 2000, pp. 127-134, vol. 29, No. 2.
Watson et al., Pneumococcal Virulence Factors and Host Immune Responses to Them. European Journal of Clinical Microbiology & Infectious Diseases, Jun. 1995, pp. 479-490, vol. 14, No. 6.
Office Action for U.S. Appl. No. 10/632,117, dated Jun. 10, 2004.
Office Action for U.S. Appl. No. 10/632,117, dated Nov. 3, 2004.
Office Action for U.S. Appl. No. 10/632,117, dated Jul. 26, 2005.
Office Action for U.S. Appl. No. 10/632,117, dated Oct. 3, 2007.
Office Action for U.S. Appl. No. 10/632,117, dated Jun. 20, 2008.
Office Action for U.S. Appl. No. 10/632,117, dated Dec. 23, 2008.
Office Action for U.S. Appl. No. 10/632,117, dated Jun. 16, 2009.
Office Action for U.S. Appl. No. 11/516,691, dated Feb. 26, 2008.
Office Action for U.S. Appl. No. 11/516,691, dated Apr. 22, 2008.
Office Action for U.S. Appl. No. 11/516,691, dated Dec. 5, 2008.
Office Action for U.S. Appl. No. 11/516,691, dated Jun. 22, 2009.
Office Action for U.S. Appl. No. 11/516,691, dated Nov. 25, 2009.
Database EMBL [Online]Streptococcus pneumoniaeadherence and virulence protein A (pavA) gene, complete cds, Nov. 4, 1999, XP002332859, retrieved from EBI accession No. EM—PRO:AF181976, Database accession No. AF181976.
Database EMBL [Online],S.gordoniipartial aldB gene, cshA gene & fbpA gene, XP0023328
Graser Jennifer
Stichting Dienst Landbouwkundig Onderzoek
TraskBritt
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