Virulence genes, proteins, and their use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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C435S004000, C435S005000, C435S006120, C435S069100, C435S252300, C435S320100, C536S023100, C536S023700, C536S024320, C424S243100

Reexamination Certificate

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06951732

ABSTRACT:
A series of genes fromStreptococcus pyogenesare shown to encode products which are implicated in virulence. The identification of these genes therefore allows attenuated microorganisms to be produced. Furthermore, the genes or their encoded products can be used in the manufacture of vaccines for therapeutic application.

REFERENCES:
patent: 0 786 519 (1997-07-01), None
patent: WO 97/13786 (1997-04-01), None
Burgess et al., The Journal of Cell Biology, 111:2129-2138, 1990.
Wessels, M.R. & M.S. Bronze (Dec. 6, 1994) “Critical role of the group A streptococcal capsule in pharyngeal colonization and infection in mice”Proceedings of the National Academy of Sciences of USA91(25):12238-12242.
Ferretti, J.J. et al. (Apr. 10, 2001) “Complete genome sequence of an M1 strain ofStreptococcus pyogenes”Proceedings of the National Academy of Sciences of USA98(8):4658-4663.

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