Virulence genes and proteins, and their use

Details Virulence genes and proteins, and their use Virulence genes and proteins, and their use

2005-01-25

2005-01-25

Smith, Lynette R. F. (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Chemical stimulation of growth or activity by addition of...

C424S001690, C435S007320, C435S041000, C435S068100, C435S069100, C435S069200, C435S069700, C435S069800, C435S070200, C435S071200, C435S091100, C435S091400, C435S173800, C435S183000, C435S193000, C435S243000, C435S252300, C436S501000, C436S815000, C530S300000, C530S324000, C530S333000, C530S350000, C930S010000, C930S200000, C930S300000, C930S310000

Reexamination Certificate

active

06846667

ABSTRACT:
The present invention is based on the identification of a series of virulence genes inE. coliK1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.

REFERENCES:
Database SPTREMBL [Online], Accession No. 069415, Aug. 1, 1998, “tatB protein (mttA2)” (XP002133195).
Database SWISSPROT [Online], Accession No. P27857, Jul. 15, 1998, “tatC protein (mttB)” (XP002133196).
Database Genbank [Online], Accession No. AJ005830, Mar. 29, 1999, Sargent: “E. colitatABCD operon” (XP002133197).
Vann, W.F. et al. (1997) “Purification and characterization of theEscherichia coliK1 neuB gene product N-acetylneuraminic acid synthase”Glycobiology7(5):697-701.
Boyd, E.F. and D.L:. Hartl (Mar. 1998) “Chromosomal regions specific to pathogenic isolates ofEscherichia colihave a phylogenetically clustered distribution”J. Bacteriol.180(5):1159-1165.
Weiner, J.H. et al. (Apr. 1998) “A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins”Cell93:93-101.
Bogsch, E.G. et al. (Jul. 1998) “An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria”J. Biol. Chem.273(29):18003-19006.
Cieslewicz, M. and E. Vimr (Jun. 1996) “Thermoregulation of kpsF, the First Region 1 gene . . .E. coliK1”J. Bacteriology178(11):3212-3220.
Sargent, F. et al. (Jul. 1998) “Overlapping functions of components of a bacterial Sec-independent protein export pathway”J. EMBO17(13):3640-3650.
Database SPTREMBL [Online], Accession No. 065938, Aug. 1, 1998, “tatA protein (mttA1)” (XP002133194).

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