Virulence-attenuating genetic deletions deleted from mycobacteri

Details Virulence-attenuating genetic deletions deleted from mycobacteri Virulence-attenuating genetic deletions deleted from mycobacteri

1995-02-17

1997-12-23

Elliott, George C.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4352402, 4352521, 4352531, 435 912, 435 6, 4353201, 536 2431, 536 2432, 536 2433, 536 221, C07H 2102, C07H 2104, C12N 121, C12Q 168

Patent

active

057006830

ABSTRACT:
The present invention provides specific genetic deletions that result in an avirulent phenotype of a mycobacterium. These deletions may be used as phenotypic markers of providing a means for distinguishing between disease-producing and non-disease producing mycobacteria.

REFERENCES:
patent: 4410660 (1983-10-01), Straus
patent: 4683202 (1987-07-01), Mullis
patent: 5171839 (1992-12-01), Patarroyo
patent: 5254459 (1993-10-01), Patarroyo et al.
Infection and Immunity, vol. 59, No. 10, issued Oct. 1991, C. Parra et al., "Isolation, characterization and molecular cloning of a specific mycobacterium tuberculosis antigen gene: identification of a species-specific sequence", pp. 3411-3417.
Abstracts of the 1994 IDSA Annual Meeting, Clin. Infect. Dis., vol. 19, issued Oct. 1994, R. Frothingham et al., "Sequence based strain differentiation in the Mycobacterium tuberculosis complex, including rapid identification of M. bovis BCG", p. 565, see abstract 10.
R. Gherna et al., "American Type Culture Collection: Catalogue of Bacteria and Phages", Eighteenth edition, published 1992, pp. 202 and 211.
Infection and Immunity, vol. 62, No. 4, issued Apr. 1994, L. Pascopella et al., "Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence", pp. 1313-1319.
Science, vol. 261, issued 10 Sep. 1993, S. Arruda et al., "Cloning of an M. Tuberculosis DNA fragment associated with entry and survival inside cells", pp. 1454-1457.
Nature, vol. 256, issued 07 Aug. 1975, C. Kohler et al., "Continuous cultures of fused cells secreting antibody of predefined specificity", pp. 495-497.
Genomics, vol. 4, issued 1989, D. Wu et al., "The ligation amplification reaction (LAR) amplification of specific DNA sequences using sequential rounds of template directed ligation", pp. 560-569.
Gene, vol. 131, issued 1993, A. Kinger et al., "Identification and cloning of genes differentially expressed in the virulent strain of mycobacterium tuberculosis", pp. 113-117.
Microbiology, vol. 141, issued 1995, J. Rodriguez et al., "Species-specific identification of mycobacterium bovis by PCR", pp. 2131-2138.
Hybridoma, vol. 13, No. 1, issued 1994, A. Arya et al., "Production and characterization of new murine monoclonal antibodies reactive to mycobacterium tuberculosis", pp. 21-30.
Li et al, "Evidence for absence of MPB64 gene in some substrains of mycobacterium bovis BCG", Inf. Immun. 61(5):1730-1734, May 1993.
Mahairas et al, "Molecular analysis of genetic differences between mycobacterium bovis BCG and virulent M. bovis", J. Bacteriol. 178(5):1274-1282, Mar. 1996.
Andersen, A. et al., Scand. J. Immunol. 34:365 (1991).
Haslov, K. et al., J. Bacteriol. 63:804 (1995).
Oettinger, T. et al., Infect. Immun. 62:2058 (1994).
Strain, S.M. et al., Biochem. Res. Comm. 77:449 (1977).
Takayama, K. et al., Antimicrob. Agents. Chemother. 2:29 (1972).

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