Virucidal substances

Details Virucidal substances Virucidal substances

1996-06-27

1998-10-20

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514564, 514561, 562561, 562564, A01N 3712, C07C22900

Patent

active

058247084

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

1. Field of the Invention
DE 34 10 956 A1 relates to antimicrobial agents obtainable by atoms, with ##STR2## in which R.sup.2 is an alkyl radical containing 1 to 4 carbon atoms or a hydrogen atom, the molar ratio of a) to b) being 1:1 to 1:2 and the reaction being carried out over a period of 0.5 to 10 hours at 60.degree. to 175.degree. C. with elimination of alcohol and/or water, and optionally propylene oxide under alkoxylation conditions known per se and optionally organic acids.
By virtue of their microbistatic and microbicidal effect on bacteria and fungi, these antimicrobial agents are suitable for solving various disinfection or preservation problems in non-therapeutic applications. For use as an active ingredient in antimicrobial formulations, they may be incorporated in liquid, paste-form or solid preparations. The corresponding preparations are used for various purposes, for example as cleaners, disinfectants and preservatives for textiles, floors, hospital equipment, medical instruments, schools, swimming pools, public transport, commercial enterprises, such as dairies, breweries and laundries.
2. Description of the Invention
The present invention relates to the use of the active substances defined above as virucidal agents.
In principle, bactericidal or fungicidal agents cannot be expected to show virucidal activity as well,
Basically, bactericides, for example any of the usual so-called active ingredients of disinfectants, are not virucidal as well. In many cases, however, they are partly virucidal against lipophilic enveloped viruses, for example against Newcastle Disease virus, herpes viruses or vaccinia virus.
A partly virucidal spectrum such as this is a known attribute of a number of surfactants, quaternary ammonium compounds and biguanides. However, these substances are either ineffectual or show inadequate activity against lipophilic, envelope-free viruses, for example adenovirus or SV 40 tumor virus.
The highest degree of virucidal activity is only achieved by very few substances, for example by aldehydes, more especially formaldehyde, glutaralde-hyde, or certain oxygen- or halogen-yielding substances. The substances in question would even destroy the hydrophilic envelope-free viruses which are the most difficult to inactivate, such as polio virus for example.
In tests, the known active substance according to DE 34 10 956 A1 showed hitherto unknown and unforeseeable effectiveness both against enveloped lipophilic viruses and against envelope-free lipophilic viruses (cf. Tables 1 and 2). Accordingly, the active substance according to DE 34 10 956 A1 which is known to be antimicrobial is also a new virucidal agent. Under comparable conditions, it shows considerably better virucidal activity than Vantocil.RTM. (a polymeric biguanide produced by ICI), cf. Table 3. This applies both to solutions in butyl diglycol and to solutions in water.


EXPERIMENTAL DATA

The virucidal performance of the active substance according to DE 34 10 956 A1 and of Vantocil.RTM. was tested against the following viruses by the DVV method (Bundesgesundheitsamt: Guidelines of the Bundesgesundheitsamt (BGA; German Federal Health Office) and the Deutsche Vereinigung zur Bekampfung der Viruskrankheiten e.V. (DW: German Association for the Control of Virus Diseases) for Testing the Effectiveness of Chemical Disinfectants Against Viruses. Zbl. Hyg. 1990; 189: 554-62):
The results of the tests involving the substances mentioned in in-use concentrations of 0.005 to 1% are set out in Tables 1 to 3 for the viruses mentioned above. The figures shown represent the reduction factors (log 10) in respect of the particular viruses for contact times of 15, 30 and 60 minutes. The abbreviations used in the Tables have the following meanings:


TABLE 1 ______________________________________ Virucidal activity of the active substance according to DE 34 10 956 A1 (50% variant with butyl diglycol as solvent). Titer reduction (log 10) of the particular viruses listed under the conditions mentioned (c

REFERENCES:
patent: 4652585 (1987-03-01), Gerhardt et al.
Bundesgensundheitsamt: Guidelines of the Bundesgesundeitsamt (BGA; German Federal Health Office) and the Deutsche Vereinigung zur Bekampfung der Viruskrankheiten e.V. 9DVV: German Association for the Control of Virus Diseases) for Testing the Effectiveness of Chemical Disinfectants Against Viruses. Zbl. Hyg. 1990; 189: 554-62).

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