Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Aldehyde doai
Patent
1988-12-20
1991-04-02
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Aldehyde doai
514696, 514697, 514698, 514705, 514934, A61K 31115, A61K 3111
Patent
active
050047574
ABSTRACT:
Very potent, stable, ordorless, and phenol-free virciudal solutions are active at high dilution when used for surface decontamination of animate and inanimate objects. The virucidal compositions described are efficacious in a matter of minutes against both the lipophilic and the more resistant hydrophilic viruses. The three active ingredients in these virucidal compositions are the glutaraldehyde monomer in equilibrium with its hydrates and polymers, hydrogen-bonded glycol molecules to eliminate aldehydes odor, and an anionic surfactant of the alkyl sulfate, alkyl sulfonate, alcohol sulfate or alkyl aryl sulfonate type. A preferred anionic surfactant would be the Sodium Dodecyl Sulfate (SDS), which exhibits strong cidal synergism against the Herpes Simplex Virus type 1 when mixed at a concentration as low as 0.0005% in diluted glutaraldehyde aqueous solutions (0.0025%). Improved virucidal killing at higher dilutions of the same formula were observed with the more resistant Coxsackie B viruses. Because of the low concentration of active ingredients, these solutions exhibit a very low toxicity, making them suitable for topical applications as antiseptics.
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Rollins John W.
Wave Energy Systems, Inc.
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