Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1994-10-31
1998-03-17
Pak, John
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424600, 424617, 424641, 424643, 514494, 514724, 514739, A61K 31045, A61K 3128, A61K 31315
Patent
active
057284040
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP93/00384, filed on Feb. 17, 1993.
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to virucidal disinfectants, more particularly for hands.
2. Discussion of Related Art
Bacteria, fungi and the envelope bacteria which are relatively easy to inactivate (for example the AIDS and hepatitis B virus) are destroyed by many known hand disinfectants (cf. VII. Liste der nach den Richtlinien der Deutschen Gesellschaft fur Hygiene und Mikrobiologie gepruften Desinfektionsverfahren (VIIth List of the Disinfection Processes Tested under the Guidelines of the German Society for Hygiene and Microbiology), Stand 31.3.1987, mhp-Verlag Wiesbaden, 1987).
However, these disinfectants have generally proved to be ineffective against envelope-free hydrophilic viruses and, in some cases, against envelope-free mildly lipophilic viruses such as, for example, entero-/picorna- or adeno- and reo viruses cf. Schoenemann et al.: Viruzide Wirkung von 30 Handedesinfektionsmitteln aus der VII. Liste der DGHM. (Virucidal Effect of 30 Hand Disinfectants from the VIIth List of the DHGM), Hyg.+Med. 14, 279-282 (1987)).
In general, therefore, important viruses of relevance in human medicine such as, for example, entero, polio, hepatitis A, ECHO, Coxsackie, corona, calici or rhino viruses cannot be adequately eliminated by known hand disinfectants. This fact can lead to the transmission of virus infections, particularly in hospitals, through contamination of the hands of patients and staff and the instruments used by them. There is also a danger of infection from contaminated surfaces.
Accordingly, the problem addressed by the present invention was to provide a virucidal disinfectant which could be used universally, but especially for hands.
It is known that pure methanol, ethanol, n-propanol, isopropanol or butanol have a distinct but limited virucidal effect in very high concentrations of around 80% or more. Against envelope-free hydrophilic viruses, this virucidal effect decreases with increasing chain length or decreasing hydrophilicity of the alcohols (Noda et al.: Virucidal Activity of Alcohols, J. Jap. Ass. Infect. Dis. 55, 355-366 (1981)). Lower concentrations of these alcohols are not sufficiently effective. Individually, pure propanol, isopropanol or butanol is definitely not sufficiently active against envelope-free hydrophilic viruses. Known mixtures of ethanol and isopropanol with a total active-substance content of 20 to 40% show no virucidal activity either.
The virucidal activity of metal salts, particularly zinc salts, has never been described before. Hitherto, virucidal activity as a disinfectant has only been claimed for lithium dodecyl sulfate in combination with a special nonionic surfactant dissolved in an aliphatic alcohol (EP 0 263 864 B1). Through its specificity, this combination does not concern the present invention.
SUMMARY OF THE INVENTION
The present invention relates to a virucidal disinfectant containing an active quantity of salts of metals of the alkaline earth metals, alkali metals, earth metals and/or metals of the first, second or third secondary group of the periodic system of elements in the form of a solution in water and/or alcohol.
DETAILED DESCRIPTION OF THE INVENTION
More particularly, it has been found that the virucidal activity of alcohols or alcohol/water mixtures with a total alcohol concentration of 40 to 90% and preferably 50 to 80% can be considerably increased by addition of base- or acid-hydrolyzed salts of metal ions of the earth metal and meta metal group of the periodic system of elements in quantities of 0.1 to 1% by weight and preferably in quantities of 0.2 to 0.6% by weight. Preferred anions of these salts are the strong inorganic acids and the weak organic acids. The corresponding hydrate salts may also be used. Normally ineffectual alcohol mixtures or alcohol/water mixtures thus develop far-reaching virucidal activity. The disinfectants may also contain small quantities of substances for improving compatibility w
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Bansemir Klaus-Peter
Hachmann Klaus
Mainz Beate
von Rheinbaben Friedrich
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Ortiz Daniel S.
Pak John
Wood John Daniel
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