Virtual prototyping and testing for medical device development

Details Virtual prototyping and testing for medical device development Virtual prototyping and testing for medical device development

2000-10-04

2010-11-23

Proctor, Jason (Department: 2123)

Data processing: structural design, modeling, simulation, and em

Simulating nonelectrical device or system

Mechanical

C703S002000, C703S011000

Reexamination Certificate

active

07840393

ABSTRACT:
A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.

REFERENCES:
patent: 4742464 (1988-05-01), Duret et al.
patent: 5150304 (1992-09-01), Berchem et al.
patent: 5233992 (1993-08-01), Holt et al.
patent: 5273038 (1993-12-01), Beavin
patent: 5365996 (1994-11-01), Crook
patent: 5506785 (1996-04-01), Blank et al.
patent: 5590261 (1996-12-01), Sclaroff et al.
patent: 5594651 (1997-01-01), St. Ville
patent: 5601084 (1997-02-01), Sheehan et al.
patent: 5612885 (1997-03-01), Love
patent: 5798924 (1998-08-01), Eufinger et al.
patent: 5880976 (1999-03-01), DiGioia, III et al.
patent: 6201543 (2001-03-01), O'Donnell et al.
patent: 6301496 (2001-10-01), Reisfeld
patent: 6381562 (2002-04-01), Keane
patent: 6463351 (2002-10-01), Clynch
patent: 2002/0068968 (2002-06-01), Hupp
patent: 2002/0103505 (2002-08-01), Thompson
patent: 574098 (1993-12-01), None
patent: WO 03/015666 (2003-02-01), None
Leotta et al., “Cross-Sectional Area Changes in Peripheral Vein Grafts Monitored by Three-Dimensional Ultrasound Imaging”; 2000 IEEE Ultrasonic Symposium; May 2000; pp. 1865-1868.
Bossart et al., “Finite Element Analysis of Human Joints”; IEEE Signal Process Society, Sep. 1996; pp. 1-2.
Dovey et al. “Finite Element Analysis Results Visualization for Unstructured Grids”; Lawrence Livermore National Laboratory, Oct. 1993; p. 4.
Holzapfel et al., Large strain analysis of soft biological membranes: Formulation and finite element analysis, Elsevier Science; Oct. 1995, p. 45-61.
Taylor et al, “Finite Element Modeling of Three-Dimensional Pulsatile Flow in the Abdominal Aorta: Relevance to Atherosclerosis”; Annals of Biomedical Engineering; vol. 26; 1998; pp. 975-987.
“Predictive Analysis at the Forefront of Medical Product Development”; MD&DI, Oct. 1999.
Rebelo et al.; “Finite element analysis for the design of Nitinol medical devices”; Pacific Consultants; 1999.
Maker et al.; “NIKE3D, A nonlinear, implicit, three-dimensional finite element code for solid and structural mechanics user's manual”; Apr. 14, 1995.
Peter J. Raboin, “Computational Mechanics Moves Ahead”, May 1998, Science & Technology Review, May 1998, pp. 1-13.
Seung Lee et al., “Automated Mesh Generation of an Arterial Bifurcation Based upon in Vivo MR Images”, Jul. 23-28, 2000, World Congress on Medical Physics and Bioengineering, pp. 1-4.
Douglas E. Speck and Donald J. Dovey; “GRIZ Finite Element Analysis Results Visualization for Unstructured Grids”; Mar. 1996; Lawrence Livermore National Laboratory; contents, pp. 1-2, 21-27.
J.R. Kelley, J.a. Tesk, and J.A. Sorensen; “Failure of All-ceramic Fixed Partial Dentures in vitro and in vivo: Analysis and Modeling”; Jun. 1995; J Dent Res 74(6); pp. 1253-1258.
Santosh G. Zachariah and Joan E. Sanders, “Interface Mechanics in Lower-Limb External Prosthetics: A Review of Finite Element Models”, 1996, IEEE Transactions on Rehabilitation Engineering, vol. 4 No. 4, pp. 288-302.
Campbell Rogers, David Y. Tseng, James C. Squire, and Elazer R. Edelman; “Balloon-Artery Interactions During Stent Placement: A Finite Element Analysis Approach to Pressure, Compliance, and Stent Design as Contributors to Vascular Injury”; 1999; American Heart Association; pp. 378-383.
Martin Zacek et al., “Numerical simulation of the blood flow in the human cardiovascular system”, 1995, Elsevier Science Ltd., pp. 13-20.
F. D. Whitcher, “Simulation of in vivo loading conditions of nitinol vascular stent structures”, 1997, Elsevier Science Ltd., pp. 1005-1011.
T. Nicholas, “Critical issues in high cycle fatigue”, 1999, International Journal of Fatigue, vol. 21, pp. S221-S231.
C. K. Chong et al., “A Prototype Simulator for Endovascular Repair of Abdominal Aortic Aneurysms”, 1997, W.B. Saunders Company Ltd., pp. 330-333.
J. De Hart, “A three-dimensional analysis of a fibre-reinforced aortic valve prosthesis,” 1998, Elsevier Science Ltd., pp. 629- 638.
Christon et al. “Visualization of High Resolution, Three-Dimensional, Nonlinear Finite Element Analyses,”Proceedings. Visualization '92(Car. No. 92Ch3201-1) (1992).
Elger et al. “The Influence of Shape on the Stresses in Model Abdominal Aortic Aneurysms,”Transactions of the ASME326:326-32 (1996).
Holzapfel et al. “Large strain analysis of soft biological membranes: Formualtion and finite element analysis,”Comp. Methods. Appl. Mech. Engrg.132:45-61 (1996).
Hoover et al. “Parallel Algorithms for Finite Element Analysis (DYNA3D/NIKE3D),” UCRL-JC-127647 Abstract. Lawrence Livermore National Laboratory Technical Publication.
How et al. “Mechanical Properties of Arteries and Arterial Grafts,” Chapter 1 ofCardiovascular BiomaterialsHasting, G.W. (ed.) London; New York: Springer-Verlag, 1992 pp. 1-35.
Lakshmiraghavan, M.Mechanical Wall Stress in Adominal Aortic Aneurysm: Towards the Development of a Clinical Tool to Predict Aneurysm Rupture. Submitted to the University of Pittsburgh, vol. 59/O9-B of Dissertaion Abstracts International p. 4948. 285 pages (1998).
Mosora et al. “Modelling the arterial wall by finite elements,”Archives Internationales de Physiologie, de Biochimica et de Biophysique101;185-91 (1992).
Mower et al. “Stress Distributions in Vascular Aneurysms: Factors Affecting Risk of Aneurysm Rupture,”J. Surgical Research55:151-61 (1993).
Papageorgiou, G.L. and N.B. Jones, “Physical Modelling of the Arterial Wall. Part2: Simulation of the Non-Linear Elasticity of the Arterial Wall,”J. Biomed. Eng.9:216-21 (1987).
Simon et al. “Finite Element Models for Arterial Wall Mechanics”J. Biomechanical Engineering115:489-96 (1993).
Tanaka et al. “Inelastic Constitutive Modeling of Arterial and Ventricular Walls,”Computational BiomechanicsHayashi, Ishikawa (eds.) Springer Press pp. 137-163.
Vito et al. “Stress Analysis of the Diseased Arterial Cross-section,” 1990 Advances in Bioengineering American Society of Mechanical Engineers, Bioengineering Division (Publication) BED v. 17, ASME:New York, (1990). pp. 273-276.
Xu et al. “Coupled Modelling of Blood Flow and Arterial Interactions by The Finite Element Method,”Proceedings of the Computers in Cardiology 1993 IEEE Computer Society PressSep. 5-8, 1993 pp. 687-690.
“Modeling the Biomechanics of Human Joints and Prosthetic Implants,”Lawrence Livermore National Laboratory(http://www-iscr.llnl.gov).
Bossart, P.L. and K. Hollerbach “Finite Element Analysis of Human Joints,”IEEE Signal Process Society 1996 International Conference on Image Processing Lausanne, Switzerland Sep. 16-19, 1996 (Preprint submitted from Lawrence Livermore National Laboratory).
Dovey, David and Thomas E. Spelce “GRIZ Finite Elemen

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