Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-09-05
1999-01-12
Achutamurthy, Ponnathapura
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4242291, 435 6, 4352351, 4353201, C07H 2104, A61K 39245, C12Q 168, C12N 700
Patent
active
058592253
ABSTRACT:
This invention provides an isolated nucleic acid molecule which encodes KSHV virion protein 26. This invention provides an isolated polypeptide molecule which encodes KSHV virion protein 26. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine and method of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.
REFERENCES:
Ades et al. (1989) Prevalence of antibodies to herpes simplex virus types 1 and 2 in pregnant women, and estimated rates of infection, J Epidemiol Commun Health 43, 53-60 (Exhibit 2).
Booy et al. (1994) Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus) , Proc Natl Acad Sci USA 91, 5652-5656 (Exhibit 3).
Corey and Spear (1986) Infection with herpes simplex viruses, N Eng J Med 314, 686-691 (Exhibit 4).
Crawford (1994) Epstein-Barr virus, In: Zuckerman et al., eds., Principles And Practice of Clinical Virology, 3d edn., New York, Wiley, pp. 109-134 (Exhibit 5).
Hornef (1995) Coincidence of Epstein-Barr virus reactivation, cyto-megalovirus infection, and rejection episodes in renal transplant recipients, Transplantation 60, 474-480 (Exhibit 6).
Tatman et al. (1994) Assembly of herpes simplex virus type 1 capsids using a panel of recombinant baculoviruses, J Gen Virol 75, 1101-1113 (Exhibit 7).
Trus et al. (1995) Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses; structural authenticity and localization of VP26, J Virol 69, 7362-7366 (Exhibit 8).
van Grunsven etl (1993) Gene mapping and expression of two immuno-dominant Epstein-Barr virus capsid proteins, J Virol 67, 3908-3916 (Exhibit 9).
Bohenzky Roy A.
Chang Yuan
Edelman Isidore S.
Moore Patrick S.
Russo James J.
Achutamurthy Ponnathapura
Bui Phuong T.
The Trustees of Columbia University in the City of New York
White John P.
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