Viral vectors whose replication and, optionally, passenger...

Details Viral vectors whose replication and, optionally, passenger... Viral vectors whose replication and, optionally, passenger...

2011-03-15

2011-03-15

Burkhart, Michael (Department: 1633)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S320100, C424S093200, C424S093600

Reexamination Certificate

active

07906312

ABSTRACT:
The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for efficient viral replication and may also control the activity of a passenger gene.

REFERENCES:
patent: 6855544 (2005-02-01), Hateboer et al.
Avvakumov, N. et al., “New tools for the construction of replication-competent adenoviral vectors with altered E1A regulation”, J. Vir. Meth., May 2002, vol. 103: pp. 41-49.
Chong, H. et al., “A system for small-molecule control of conditionally replication competent adenoviral vectors”, Mol. Ther., Feb. 2002, vol. 5: pp. 195-203.

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