Viral vectors having reduced virulence

Details Viral vectors having reduced virulence Viral vectors having reduced virulence

2005-09-13

2005-09-13

Guzo, David (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S093600

Reexamination Certificate

active

06942855

ABSTRACT:
The present invention provides recombinant vaccinia virus having a deletion of the region encoding the C-terminal seven amino acids of the E3L gene product and comprising exogenous DNA. Compositions comprising the recombinant vaccinia virus and methods of use thereof are also provided.

REFERENCES:
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patent: 6372455 (2002-04-01), Jacobs et al.
patent: 2002/0110565 (2002-08-01), Jacobs et al.
patent: 9955910 (1999-11-01), None
patent: 0062735 (2000-10-01), None
patent: 0073487 (2000-12-01), None
Chang et al., J. Virol., 1995, vol. 69, No. 10, pp. 6605-6608.
Chang et al., PNAS, 1992, vol. 89, pp. 4825-4829.
U.S. Appl. No. 09/887,295, filed Aug. 15, 2002, Jacobs et al.
Brandt et al., “Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model”, J. Virology 75:850-856, 2001.
Shors et al., “Complementation of Vaccinia Virus Deleted of the E3L Gene by Mutants of E3L”, Virology 239:269-276, 1997.
Kibler et al., “Double-Stranded RNA Is a Trigger for Apoptosis in Vaccinia Virus-Infected Cells” Journal of Virology 71:1992-2003, 1997.
Beattie et al., “Host-Range Restriction of Vaccinia Virus E3L—Specific Deletion Mutants”, Viru Genes, 1996, vol. 12, pp. 89-94.
Beattie et al., “Reversal of the Interferon-Sensitive Phenotype of a Vaccinia Virus Lacking E3L by Expression of the Reovirus S4 Gene”, Journal of Virology, vol. 69, No. 1, Jan. 1995, pp. 499-505.
Chang et al., “Indentification of a Conserved Motif That is Necessary for Binding of the Vaccinia Virus E3L Gene Products to Double-Stranded RNA”, Virology 194:537-547, 1993.

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