Chemistry: molecular biology and microbiology – Vector – per se
Patent
1994-12-23
1998-05-19
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
435235, 4351723, 514 44, C12N 1563
Patent
active
057534993
ABSTRACT:
The invention concerns an improvement in the art of inserting and expressing foreign gene into eukaryotic cells. The invention particularly concerns methods and compositions whereby viral vectors can be used to insert and express foreign genes into specifically cells having particular differentiation antigens. A method of determining which differentiation antigens can be used is taught. The invention encompasses complexes of viral particles and adapters that cause the binding and internalization of the vector particles such that a gene of interest in the particle is expressed.
REFERENCES:
patent: 5328985 (1994-07-01), Sano et al.
Roux et al., Proc. Natl. Acad. Sci. USA, 86:9079-9083 (1989).
Sano et al., Bio/Technology, 9:1378-1381 (1991).
Etienne-Julan et al., Bone Marrow Transplantation, 9(Suppl.1):139-142.
Etienne-Julan et al., J. General Virology, 73:3251-3255 (1992).
Roux et al., Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation, H34:153-164 (1989).
Etienne-Julan et al., Human Gene Transfer, 219:177-184 (1991).
Meruelo Daniel
Ono Koichi
Pampeno Christine
Chambers Jasemine C.
Clark Deborah J. R.
New York University
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