Viral vector coding glycoprotein of HIV-1

Details Viral vector coding glycoprotein of HIV-1 Viral vector coding glycoprotein of HIV-1

1991-09-24

1992-12-08

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 5, 435 691, 435 697, 4351723, 4352402, 435974, 4353201, 530395, 930221, 935 32, 935 34, 935 70, C12N 1549, C12N 1586, C12N 510, C12P 2102

Patent

active

051697637

ABSTRACT:
A viral vector comprising at least a portion of the genome of the HIV virus, a gene coding gp160 glycoprotein of the envelope of the HIV virus, as well as the elements providing for the expression of the glycoprotein in cells, wherein the gp160 is expressed as a non-cleavable protein.

REFERENCES:
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S. L. Hu et al., Nature, vol. 320, Apr. 10, 1986, "Expression of AIDS virus envelope gene in recombinant vaccinia viruses", pp. 537-540.
M. P. Kieny et al., Bio/Technology, vol. 4, No. 9, Sep. 1986, "AIDS virus env protein expressed from a recombinant vaccinia virus" pp. 790-795.
R. Sanchez-Pescador et al., Science, vol. 227, Feb. 1, 1985, "Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2)", pp. 484-492.
L. A. Lasky et al., Science, vol. 233, Jul. 11, 1986, "Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein", pp. 209-212.
M. P. Kieny et al., Nature vol. 312, No. 5990, Nov. 8, 1984, "Expression of rabies virus glycoprotein from a recombinant vaccinia virus", pp. 163-166.

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